Interleaved diffusion-weighted improved by adaptive partial-Fourier and multiband multiplexed sensitivity-encoding reconstruction

Hing Chiu Chang, Shayan Guhaniyogi, Nan Kuei Chen

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Purpose We report a series of techniques to reliably eliminate artifacts in interleaved echo-planar imaging (EPI) based diffusion-weighted imaging (DWI). Methods First, we integrate the previously reported multiplexed sensitivity encoding (MUSE) algorithm with a new adaptive Homodyne partial-Fourier reconstruction algorithm, so that images reconstructed from interleaved partial-Fourier DWI data are free from artifacts even in the presence of either (a) motion-induced k-space energy peak displacement, or (b) susceptibility field gradient induced fast phase changes. Second, we generalize the previously reported single-band MUSE framework to multiband MUSE, so that both through-plane and in-plane aliasing artifacts in multiband multishot interleaved DWI data can be effectively eliminated. Results The new adaptive Homodyne-MUSE reconstruction algorithm reliably produces high-quality and high-resolution DWI, eliminating residual artifacts in images reconstructed with previously reported methods. Furthermore, the generalized MUSE algorithm is compatible with multiband and high-throughput DWI. Conclusion The integration of the multiband and adaptive Homodyne-MUSE algorithms significantly improves the spatial-resolution, image quality, and scan throughput of interleaved DWI. We expect that the reported reconstruction framework will play an important role in enabling high-resolution DWI for both neuroscience research and clinical uses. Magn Reson Med 73:1872-1884, 2015.

Original languageEnglish (US)
Pages (from-to)1872-1884
Number of pages13
JournalMagnetic Resonance in Medicine
Issue number5
StatePublished - May 1 2015
Externally publishedYes


  • artifact correction
  • diffusion-weighted imaging
  • echo-planar imaging
  • multiplexed sensitivity encoding

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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