Interference of nuclear speckles: A nexus of RNA foci, dipeptide repeats, and mis-splicing in C9ORF72 ALS/FTD

Haining Zhu

doi:10.1016/j.neuron.2024.10.001

Interference of nuclear speckles: A nexus of RNA foci, dipeptide repeats, and mis-splicing in C9ORF72 ALS/FTD

Haining Zhu

Pharmacology and Toxicology

Research output: Contribution to journal › Comment/debate › peer-review

4 Scopus citations

Abstract

In this issue of Neuron, Wu et al.¹ show that nuclear speckle proteins are sequestered by both nuclear RNA foci and cytoplasmic dipeptide repeat aggregates in C9ORF72-ALS/FTD. Consequently, dysregulation of splicing induces widespread splicing alterations and contributes to neurodegeneration.

Original language	English (US)
Pages (from-to)	3375-3377
Number of pages	3
Journal	Neuron
Volume	112
Issue number	20
DOIs	https://doi.org/10.1016/j.neuron.2024.10.001
State	Published - Oct 23 2024

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1016/j.neuron.2024.10.001

Cite this

@article{23378c9a38c44f7fb1d2c1fcef19827a,

title = "Interference of nuclear speckles: A nexus of RNA foci, dipeptide repeats, and mis-splicing in C9ORF72 ALS/FTD",

abstract = "In this issue of Neuron, Wu et al.1 show that nuclear speckle proteins are sequestered by both nuclear RNA foci and cytoplasmic dipeptide repeat aggregates in C9ORF72-ALS/FTD. Consequently, dysregulation of splicing induces widespread splicing alterations and contributes to neurodegeneration.",

author = "Haining Zhu",

note = "Publisher Copyright: {\textcopyright} 2024",

year = "2024",

month = oct,

day = "23",

doi = "10.1016/j.neuron.2024.10.001",

language = "English (US)",

volume = "112",

pages = "3375--3377",

journal = "Neuron",

issn = "0896-6273",

publisher = "Cell Press",

number = "20",

}

TY - JOUR

T1 - Interference of nuclear speckles

T2 - A nexus of RNA foci, dipeptide repeats, and mis-splicing in C9ORF72 ALS/FTD

AU - Zhu, Haining

PY - 2024/10/23

Y1 - 2024/10/23

N2 - In this issue of Neuron, Wu et al.1 show that nuclear speckle proteins are sequestered by both nuclear RNA foci and cytoplasmic dipeptide repeat aggregates in C9ORF72-ALS/FTD. Consequently, dysregulation of splicing induces widespread splicing alterations and contributes to neurodegeneration.

AB - In this issue of Neuron, Wu et al.1 show that nuclear speckle proteins are sequestered by both nuclear RNA foci and cytoplasmic dipeptide repeat aggregates in C9ORF72-ALS/FTD. Consequently, dysregulation of splicing induces widespread splicing alterations and contributes to neurodegeneration.

UR - https://www.scopus.com/pages/publications/85207332505

UR - https://www.scopus.com/pages/publications/85207332505#tab=citedBy

U2 - 10.1016/j.neuron.2024.10.001

DO - 10.1016/j.neuron.2024.10.001

M3 - Comment/debate

C2 - 39447539

AN - SCOPUS:85207332505

SN - 0896-6273

VL - 112

SP - 3375

EP - 3377

JO - Neuron

JF - Neuron

IS - 20

ER -

Interference of nuclear speckles: A nexus of RNA foci, dipeptide repeats, and mis-splicing in C9ORF72 ALS/FTD

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this