TY - JOUR
T1 - Interference of nuclear speckles
T2 - A nexus of RNA foci, dipeptide repeats, and mis-splicing in C9ORF72 ALS/FTD
AU - Zhu, Haining
N1 - Publisher Copyright:
© 2024
PY - 2024/10/23
Y1 - 2024/10/23
N2 - In this issue of Neuron, Wu et al.1 show that nuclear speckle proteins are sequestered by both nuclear RNA foci and cytoplasmic dipeptide repeat aggregates in C9ORF72-ALS/FTD. Consequently, dysregulation of splicing induces widespread splicing alterations and contributes to neurodegeneration.
AB - In this issue of Neuron, Wu et al.1 show that nuclear speckle proteins are sequestered by both nuclear RNA foci and cytoplasmic dipeptide repeat aggregates in C9ORF72-ALS/FTD. Consequently, dysregulation of splicing induces widespread splicing alterations and contributes to neurodegeneration.
UR - http://www.scopus.com/inward/record.url?scp=85207332505&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85207332505&partnerID=8YFLogxK
U2 - 10.1016/j.neuron.2024.10.001
DO - 10.1016/j.neuron.2024.10.001
M3 - Comment/debate
C2 - 39447539
AN - SCOPUS:85207332505
SN - 0896-6273
VL - 112
SP - 3375
EP - 3377
JO - Neuron
JF - Neuron
IS - 20
ER -