Intentional use of carbapenem antibiotics for valproic acid toxicity: A case report

M. A. Khobrani; S. W. Dudley; Y. C. Huckleberry; B. J. Kopp; A. D. Biggs; R. N.E. French; Farshad Shirazi; Brian L Erstad

doi:10.1111/jcpt.12705

Intentional use of carbapenem antibiotics for valproic acid toxicity: A case report

M. A. Khobrani, S. W. Dudley, Y. C. Huckleberry, B. J. Kopp, A. D. Biggs, R. N.E. French, Farshad Shirazi, Brian L Erstad

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

What is known and objective: The interaction between valproic acid (VPA) and carbapenem antibiotics is well described with previous reports suggesting a reduction in VPA half-life between 47% and 90%. As described in this case, this interaction might be beneficial in the setting of toxic VPA ingestion. Case description: An intubated, unresponsive patient arrived via emergency medical services after toxic VPA ingestion. Meropenem was prescribed for a suspected pneumonia and to take advantage of the VPA interaction. We observed a 56% decline in half-life with short-term meropenem dosing and an improvement in mental status shortly after administration. What is new and conclusion: Our findings suggest a potential role for short-term carbapenem therapy for VPA overdose.

Original language	English (US)
Pages (from-to)	723-725
Number of pages	3
Journal	Journal of Clinical Pharmacy and Therapeutics
Volume	43
Issue number	5
DOIs	https://doi.org/10.1111/jcpt.12705
State	Published - Oct 2018

Keywords

carbapenem interaction
valproic acid interaction
valproic acid overdose
valproic acid toxicity

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

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10.1111/jcpt.12705

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title = "Intentional use of carbapenem antibiotics for valproic acid toxicity: A case report",

abstract = "What is known and objective: The interaction between valproic acid (VPA) and carbapenem antibiotics is well described with previous reports suggesting a reduction in VPA half-life between 47% and 90%. As described in this case, this interaction might be beneficial in the setting of toxic VPA ingestion. Case description: An intubated, unresponsive patient arrived via emergency medical services after toxic VPA ingestion. Meropenem was prescribed for a suspected pneumonia and to take advantage of the VPA interaction. We observed a 56% decline in half-life with short-term meropenem dosing and an improvement in mental status shortly after administration. What is new and conclusion: Our findings suggest a potential role for short-term carbapenem therapy for VPA overdose.",

keywords = "carbapenem interaction, valproic acid interaction, valproic acid overdose, valproic acid toxicity",

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doi = "10.1111/jcpt.12705",

language = "English (US)",

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T2 - A case report

AU - Khobrani, M. A.

AU - Dudley, S. W.

AU - Huckleberry, Y. C.

AU - Kopp, B. J.

AU - Biggs, A. D.

AU - French, R. N.E.

AU - Shirazi, Farshad

AU - Erstad, Brian L

PY - 2018/10

Y1 - 2018/10

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Intentional use of carbapenem antibiotics for valproic acid toxicity: A case report

Abstract

Keywords

ASJC Scopus subject areas

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