TY - GEN
T1 - Integration and Testing of the Hybrid Gamma Cameras for AdaptiSPECT-C
AU - Richards, R. Garrett
AU - Ruiz-Gonzalez, Maria
AU - Doty, Kimberly J.
AU - Auer, Benjamin
AU - Kupinski, Matthew A.
AU - King, Michael A.
AU - Kuo, Phillip H
AU - Furenlid, Lars R.
N1 - Funding Information:
Extended abstract submitted December 14, 2021. This work was supported in part by NIH/NIBIB Grant R01-EB022521. R. Garrett Richards was partially supported by the Biomedical Imaging and Spectroscopy Fellowship, NIH grant T32-EB000809.
Publisher Copyright:
© 2021 IEEE.
PY - 2021
Y1 - 2021
N2 - Recent advances in scintillation light sensors are enabling new designs for single-photon-emission computed tomography (SPECT) cameras for use in nuclear medicine, achieving higher sensitivity and spatial resolution than previously possible. One such camera is AdaptiSPECT-C: a new stationary and adaptive SPECT system designed for clinical whole-brain imaging. It employs a 24-stationary-camera configuration in conjunction with multi-pinhole apertures, significantly increasing its overall sensitivity to gamma radiation. Each of the five pinholes assigned to a camera can actively select among several different aperture diameters and a shuttered state; the latter function enabling the acquisition of both non-multiplexed and multiplexed image data in a single session.Each 18-cm-square camera in AdaptiSPECT-C houses 25 photomultiplier tubes (PMTs) and 24 multi-pixel photon counters (MPPCs). This combination results in a camera that achieves uniformly high spatial resolution across the entire crystal area. In this work we present the combined MPPC/PMT hybrid camera design, prioritizing modularity and space efficiency. We also cover schematics for the front-end electronics and their hardware integration, specifically highlighting initial test pulses from the two sensor types. The results of said testing show promise for the eventual merging of hybrid signal information into a comprehensive dataset during real world image acquisitions. Finally, we present preliminary calibration results and compare to predictions based on light-transport simulations.
AB - Recent advances in scintillation light sensors are enabling new designs for single-photon-emission computed tomography (SPECT) cameras for use in nuclear medicine, achieving higher sensitivity and spatial resolution than previously possible. One such camera is AdaptiSPECT-C: a new stationary and adaptive SPECT system designed for clinical whole-brain imaging. It employs a 24-stationary-camera configuration in conjunction with multi-pinhole apertures, significantly increasing its overall sensitivity to gamma radiation. Each of the five pinholes assigned to a camera can actively select among several different aperture diameters and a shuttered state; the latter function enabling the acquisition of both non-multiplexed and multiplexed image data in a single session.Each 18-cm-square camera in AdaptiSPECT-C houses 25 photomultiplier tubes (PMTs) and 24 multi-pixel photon counters (MPPCs). This combination results in a camera that achieves uniformly high spatial resolution across the entire crystal area. In this work we present the combined MPPC/PMT hybrid camera design, prioritizing modularity and space efficiency. We also cover schematics for the front-end electronics and their hardware integration, specifically highlighting initial test pulses from the two sensor types. The results of said testing show promise for the eventual merging of hybrid signal information into a comprehensive dataset during real world image acquisitions. Finally, we present preliminary calibration results and compare to predictions based on light-transport simulations.
KW - gamma-ray detectors
KW - molecular imaging
KW - silicon photomultipliers
KW - SiPMs
KW - SPECT
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U2 - 10.1109/NSS/MIC44867.2021.9875659
DO - 10.1109/NSS/MIC44867.2021.9875659
M3 - Conference contribution
AN - SCOPUS:85139089706
T3 - 2021 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2021 and 28th International Symposium on Room-Temperature Semiconductor Detectors, RTSD 2022
BT - 2021 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2021 and 28th International Symposium on Room-Temperature Semiconductor Detectors, RTSD 2022
A2 - Tomita, Hideki
A2 - Nakamura, Tatsuya
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2021 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2021
Y2 - 16 October 2021 through 23 October 2021
ER -