Integration and Testing of the Hybrid Gamma Cameras for AdaptiSPECT-C

R. Garrett Richards; Maria Ruiz-Gonzalez; Kimberly J. Doty; Benjamin Auer; Matthew A. Kupinski; Michael A. King; Phillip H. Kuo; Lars R. Furenlid

doi:10.1109/NSS/MIC44867.2021.9875659

Integration and Testing of the Hybrid Gamma Cameras for AdaptiSPECT-C

R. Garrett Richards, Maria Ruiz-Gonzalez, Kimberly J. Doty, Benjamin Auer, Matthew A. Kupinski, Michael A. King, Phillip H. Kuo, Lars R. Furenlid

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Abstract

Recent advances in scintillation light sensors are enabling new designs for single-photon-emission computed tomography (SPECT) cameras for use in nuclear medicine, achieving higher sensitivity and spatial resolution than previously possible. One such camera is AdaptiSPECT-C: a new stationary and adaptive SPECT system designed for clinical whole-brain imaging. It employs a 24-stationary-camera configuration in conjunction with multi-pinhole apertures, significantly increasing its overall sensitivity to gamma radiation. Each of the five pinholes assigned to a camera can actively select among several different aperture diameters and a shuttered state; the latter function enabling the acquisition of both non-multiplexed and multiplexed image data in a single session.Each 18-cm-square camera in AdaptiSPECT-C houses 25 photomultiplier tubes (PMTs) and 24 multi-pixel photon counters (MPPCs). This combination results in a camera that achieves uniformly high spatial resolution across the entire crystal area. In this work we present the combined MPPC/PMT hybrid camera design, prioritizing modularity and space efficiency. We also cover schematics for the front-end electronics and their hardware integration, specifically highlighting initial test pulses from the two sensor types. The results of said testing show promise for the eventual merging of hybrid signal information into a comprehensive dataset during real world image acquisitions. Finally, we present preliminary calibration results and compare to predictions based on light-transport simulations.

Original language	English (US)
Title of host publication	2021 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2021 and 28th International Symposium on Room-Temperature Semiconductor Detectors, RTSD 2022
Editors	Hideki Tomita, Tatsuya Nakamura
Publisher	Institute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)	9781665421133
DOIs	https://doi.org/10.1109/NSS/MIC44867.2021.9875659
State	Published - 2021
Event	2021 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2021 - Virtual, Yokohama, Japan Duration: Oct 16 2021 → Oct 23 2021

Publication series

Name	2021 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2021 and 28th International Symposium on Room-Temperature Semiconductor Detectors, RTSD 2022

Conference

Conference	2021 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2021
Country/Territory	Japan
City	Virtual, Yokohama
Period	10/16/21 → 10/23/21

Keywords

SPECT
SiPMs
gamma-ray detectors
molecular imaging
silicon photomultipliers

ASJC Scopus subject areas

Nuclear Energy and Engineering
Health Informatics
Radiology Nuclear Medicine and imaging
Nuclear and High Energy Physics

Access to Document

10.1109/NSS/MIC44867.2021.9875659

Cite this

Richards, R. G., Ruiz-Gonzalez, M., Doty, K. J., Auer, B., Kupinski, M. A., King, M. A., Kuo, P. H., & Furenlid, L. R. (2021). Integration and Testing of the Hybrid Gamma Cameras for AdaptiSPECT-C. In H. Tomita, & T. Nakamura (Eds.), 2021 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2021 and 28th International Symposium on Room-Temperature Semiconductor Detectors, RTSD 2022 (2021 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2021 and 28th International Symposium on Room-Temperature Semiconductor Detectors, RTSD 2022). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NSS/MIC44867.2021.9875659

Integration and Testing of the Hybrid Gamma Cameras for AdaptiSPECT-C. / Richards, R. Garrett; Ruiz-Gonzalez, Maria; Doty, Kimberly J. et al.
2021 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2021 and 28th International Symposium on Room-Temperature Semiconductor Detectors, RTSD 2022. ed. / Hideki Tomita; Tatsuya Nakamura. Institute of Electrical and Electronics Engineers Inc., 2021. (2021 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2021 and 28th International Symposium on Room-Temperature Semiconductor Detectors, RTSD 2022).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Richards, RG, Ruiz-Gonzalez, M, Doty, KJ, Auer, B, Kupinski, MA, King, MA, Kuo, PH & Furenlid, LR 2021, Integration and Testing of the Hybrid Gamma Cameras for AdaptiSPECT-C. in H Tomita & T Nakamura (eds), 2021 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2021 and 28th International Symposium on Room-Temperature Semiconductor Detectors, RTSD 2022. 2021 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2021 and 28th International Symposium on Room-Temperature Semiconductor Detectors, RTSD 2022, Institute of Electrical and Electronics Engineers Inc., 2021 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2021, Virtual, Yokohama, Japan, 10/16/21. https://doi.org/10.1109/NSS/MIC44867.2021.9875659

Richards RG, Ruiz-Gonzalez M, Doty KJ, Auer B, Kupinski MA, King MA et al. Integration and Testing of the Hybrid Gamma Cameras for AdaptiSPECT-C. In Tomita H, Nakamura T, editors, 2021 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2021 and 28th International Symposium on Room-Temperature Semiconductor Detectors, RTSD 2022. Institute of Electrical and Electronics Engineers Inc. 2021. (2021 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2021 and 28th International Symposium on Room-Temperature Semiconductor Detectors, RTSD 2022). doi: 10.1109/NSS/MIC44867.2021.9875659

Richards, R. Garrett ; Ruiz-Gonzalez, Maria ; Doty, Kimberly J. et al. / Integration and Testing of the Hybrid Gamma Cameras for AdaptiSPECT-C. 2021 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2021 and 28th International Symposium on Room-Temperature Semiconductor Detectors, RTSD 2022. editor / Hideki Tomita ; Tatsuya Nakamura. Institute of Electrical and Electronics Engineers Inc., 2021. (2021 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2021 and 28th International Symposium on Room-Temperature Semiconductor Detectors, RTSD 2022).

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title = "Integration and Testing of the Hybrid Gamma Cameras for AdaptiSPECT-C",

abstract = "Recent advances in scintillation light sensors are enabling new designs for single-photon-emission computed tomography (SPECT) cameras for use in nuclear medicine, achieving higher sensitivity and spatial resolution than previously possible. One such camera is AdaptiSPECT-C: a new stationary and adaptive SPECT system designed for clinical whole-brain imaging. It employs a 24-stationary-camera configuration in conjunction with multi-pinhole apertures, significantly increasing its overall sensitivity to gamma radiation. Each of the five pinholes assigned to a camera can actively select among several different aperture diameters and a shuttered state; the latter function enabling the acquisition of both non-multiplexed and multiplexed image data in a single session.Each 18-cm-square camera in AdaptiSPECT-C houses 25 photomultiplier tubes (PMTs) and 24 multi-pixel photon counters (MPPCs). This combination results in a camera that achieves uniformly high spatial resolution across the entire crystal area. In this work we present the combined MPPC/PMT hybrid camera design, prioritizing modularity and space efficiency. We also cover schematics for the front-end electronics and their hardware integration, specifically highlighting initial test pulses from the two sensor types. The results of said testing show promise for the eventual merging of hybrid signal information into a comprehensive dataset during real world image acquisitions. Finally, we present preliminary calibration results and compare to predictions based on light-transport simulations.",

keywords = "SPECT, SiPMs, gamma-ray detectors, molecular imaging, silicon photomultipliers",

author = "Richards, {R. Garrett} and Maria Ruiz-Gonzalez and Doty, {Kimberly J.} and Benjamin Auer and Kupinski, {Matthew A.} and King, {Michael A.} and Kuo, {Phillip H.} and Furenlid, {Lars R.}",

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doi = "10.1109/NSS/MIC44867.2021.9875659",

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series = "2021 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2021 and 28th International Symposium on Room-Temperature Semiconductor Detectors, RTSD 2022",

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AU - Richards, R. Garrett

AU - Ruiz-Gonzalez, Maria

AU - Doty, Kimberly J.

AU - Auer, Benjamin

AU - Kupinski, Matthew A.

AU - King, Michael A.

AU - Kuo, Phillip H.

AU - Furenlid, Lars R.

PY - 2021

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N2 - Recent advances in scintillation light sensors are enabling new designs for single-photon-emission computed tomography (SPECT) cameras for use in nuclear medicine, achieving higher sensitivity and spatial resolution than previously possible. One such camera is AdaptiSPECT-C: a new stationary and adaptive SPECT system designed for clinical whole-brain imaging. It employs a 24-stationary-camera configuration in conjunction with multi-pinhole apertures, significantly increasing its overall sensitivity to gamma radiation. Each of the five pinholes assigned to a camera can actively select among several different aperture diameters and a shuttered state; the latter function enabling the acquisition of both non-multiplexed and multiplexed image data in a single session.Each 18-cm-square camera in AdaptiSPECT-C houses 25 photomultiplier tubes (PMTs) and 24 multi-pixel photon counters (MPPCs). This combination results in a camera that achieves uniformly high spatial resolution across the entire crystal area. In this work we present the combined MPPC/PMT hybrid camera design, prioritizing modularity and space efficiency. We also cover schematics for the front-end electronics and their hardware integration, specifically highlighting initial test pulses from the two sensor types. The results of said testing show promise for the eventual merging of hybrid signal information into a comprehensive dataset during real world image acquisitions. Finally, we present preliminary calibration results and compare to predictions based on light-transport simulations.

AB - Recent advances in scintillation light sensors are enabling new designs for single-photon-emission computed tomography (SPECT) cameras for use in nuclear medicine, achieving higher sensitivity and spatial resolution than previously possible. One such camera is AdaptiSPECT-C: a new stationary and adaptive SPECT system designed for clinical whole-brain imaging. It employs a 24-stationary-camera configuration in conjunction with multi-pinhole apertures, significantly increasing its overall sensitivity to gamma radiation. Each of the five pinholes assigned to a camera can actively select among several different aperture diameters and a shuttered state; the latter function enabling the acquisition of both non-multiplexed and multiplexed image data in a single session.Each 18-cm-square camera in AdaptiSPECT-C houses 25 photomultiplier tubes (PMTs) and 24 multi-pixel photon counters (MPPCs). This combination results in a camera that achieves uniformly high spatial resolution across the entire crystal area. In this work we present the combined MPPC/PMT hybrid camera design, prioritizing modularity and space efficiency. We also cover schematics for the front-end electronics and their hardware integration, specifically highlighting initial test pulses from the two sensor types. The results of said testing show promise for the eventual merging of hybrid signal information into a comprehensive dataset during real world image acquisitions. Finally, we present preliminary calibration results and compare to predictions based on light-transport simulations.

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KW - SiPMs

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PB - Institute of Electrical and Electronics Engineers Inc.

T2 - 2021 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2021

Y2 - 16 October 2021 through 23 October 2021

ER -

Integration and Testing of the Hybrid Gamma Cameras for AdaptiSPECT-C

Abstract

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Keywords

ASJC Scopus subject areas

Access to Document

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