Integrating nanooptical biosensors into nucleic acid testing devices

Qi Huo Wei; Jian Gu; Chia Fu Chou; Frederic Zenhausern

doi:10.1117/12.537799

Integrating nanooptical biosensors into nucleic acid testing devices

Qi Huo Wei, Jian Gu, Chia Fu Chou, Frederic Zenhausern

Research output: Contribution to journal › Conference article › peer-review

Abstract

Nano optical biosensors employ the interaction between biomolecules and light confined in nanometer scale structures to report the bio-recognition events. This small scale sensing area/volume can ensure that small amount of biorecognition events could be detected. The exceptional sensitivity and high spatial density of nano optical biosensors make them unique in practical applications in nucleic acid detection. Lab-on-a-Chip systems provide the capabilities of separation, cell lysing, polymerase chain reaction (PCR), allowing finishing bio agent detection processes on a chip. In this paper, we present our recent efforts on integrating some novel nanooptical biosensors into Lab-on-a-Chip systems and some preliminary test results.

Original language	English (US)
Pages (from-to)	45-53
Number of pages	9
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	5363
DOIs	https://doi.org/10.1117/12.537799
State	Published - 2004
Event	Emerging Optoelectronic Applications - San Jose, CA, United States Duration: Jan 26 2004 → Jan 27 2004

Keywords

Nano Optical Biosensors
Nucleic acid based bioprobes
Surface Plasmon Resonance

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

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10.1117/12.537799

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title = "Integrating nanooptical biosensors into nucleic acid testing devices",

abstract = "Nano optical biosensors employ the interaction between biomolecules and light confined in nanometer scale structures to report the bio-recognition events. This small scale sensing area/volume can ensure that small amount of biorecognition events could be detected. The exceptional sensitivity and high spatial density of nano optical biosensors make them unique in practical applications in nucleic acid detection. Lab-on-a-Chip systems provide the capabilities of separation, cell lysing, polymerase chain reaction (PCR), allowing finishing bio agent detection processes on a chip. In this paper, we present our recent efforts on integrating some novel nanooptical biosensors into Lab-on-a-Chip systems and some preliminary test results.",

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AU - Wei, Qi Huo

AU - Gu, Jian

AU - Chou, Chia Fu

AU - Zenhausern, Frederic

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N2 - Nano optical biosensors employ the interaction between biomolecules and light confined in nanometer scale structures to report the bio-recognition events. This small scale sensing area/volume can ensure that small amount of biorecognition events could be detected. The exceptional sensitivity and high spatial density of nano optical biosensors make them unique in practical applications in nucleic acid detection. Lab-on-a-Chip systems provide the capabilities of separation, cell lysing, polymerase chain reaction (PCR), allowing finishing bio agent detection processes on a chip. In this paper, we present our recent efforts on integrating some novel nanooptical biosensors into Lab-on-a-Chip systems and some preliminary test results.

AB - Nano optical biosensors employ the interaction between biomolecules and light confined in nanometer scale structures to report the bio-recognition events. This small scale sensing area/volume can ensure that small amount of biorecognition events could be detected. The exceptional sensitivity and high spatial density of nano optical biosensors make them unique in practical applications in nucleic acid detection. Lab-on-a-Chip systems provide the capabilities of separation, cell lysing, polymerase chain reaction (PCR), allowing finishing bio agent detection processes on a chip. In this paper, we present our recent efforts on integrating some novel nanooptical biosensors into Lab-on-a-Chip systems and some preliminary test results.

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KW - Nucleic acid based bioprobes

KW - Surface Plasmon Resonance

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Integrating nanooptical biosensors into nucleic acid testing devices

Abstract

Keywords

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