Integrating differentiation and cancer: The Nkx3.1 homeobox gene in prostate organogenesis and carcinogenesis

Cory Abate-Shen, Michael M. Shen, Edward Gelmann

Research output: Contribution to journalReview articlepeer-review

102 Scopus citations

Abstract

Several tissue-specific regulatory genes have been found to play essential roles in both organogenesis and carcinogenesis. In the prostate, the Nkx3.1 homeobox gene plays an important role in normal differentiation of the prostatic epithelium while its loss of function is an initiating event in prostate carcinogenesis in both mouse models and human patients. Thus, the Nkx3.1 homeobox gene provides a paradigm for understanding the relationship between normal differentiation and cancer, as well as studying the roles of homeobox genes in these processes. Here, we review recent findings concerning the roles of Nkx3.1 in development and discuss how its normal function is disrupted in processes of early prostate carcinogenesis.

Original languageEnglish (US)
Pages (from-to)717-727
Number of pages11
JournalDifferentiation
Volume76
Issue number6
DOIs
StatePublished - Jul 2008
Externally publishedYes

Keywords

  • Homeobox
  • Nkx3.1
  • Prostate

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology
  • Cancer Research

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