The oncologic outcome and the total dose are highly correlated with the treatment by ionizing radiation. The dose increase (total or per fraction) may provoke late-side effects that are potentially irreversible. The radiation-induced CD8 lymphocyte apoptotic value and the molecular modifications within the lymphocyte are capable of predicting the level of risk of developing late-side effects after curative intent radiotherapy. In this review, we present the different blood assays in this setting and discuss the current possibilities of researches, namely those involving the proteomic process.
|Translated title of the contribution
|Interest of blood markers in predicting radiation-induced toxicity
|Number of pages
|Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique
|Published - Aug 2011
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging