Insulin growth factor 1 increases vascular smooth muscle nitric oxide production

R. Muniyappa, M. F. Walsh, J. S. Rangi, R. M. Zayas, P. R. Standley, J. L. Ram, J. R. Sowers

Research output: Contribution to journalArticlepeer-review

67 Scopus citations


Insulin like growth factor 1 (IGF-1) vasodilates, increases blood flow and lowers blood pressure; nitric oxide (NO) has been suggested to mediate some of these effects. We studied the role of IGF-1 in the regulation of NO production in vascular smooth muscle cells (VSMC). IGF-1 induced a concentration and time-dependent increase in NO release from endothelium-denuded aortic rings. Pre-incubation with cycloheximide or aminoguanidine blocked IGF-1-stimulated NO release. In addition, a six-fold increase in NO production by VSMC was seen upon incubation with IGF-1. These results suggest that IGF-1 induces NO release in VSMC through a process that involves new protein synthesis and the inducible isoform of nitric oxide synthase.

Original languageEnglish (US)
Pages (from-to)925-931
Number of pages7
JournalLife Sciences
Issue number9
StatePublished - Jul 25 1997


  • Aminoguanidine
  • IGF-1
  • Nitric oxide
  • Vascular smooth muscle cells

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • Pharmacology, Toxicology and Pharmaceutics(all)


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