Insulin effect on amino acid uptake by unloaded rat hindlimb muscles

S. R. Jaspers; M. E. Tischler

doi:10.1055/s-2007-1010771

Insulin effect on amino acid uptake by unloaded rat hindlimb muscles

S. R. Jaspers, M. E. Tischler

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

This study considered whether unloading might also alter muscle AIB uptake and its regulation by insulin. Unloading by suspension of the rat hindlimb leads to atrophy of the soleus with little change in mass of the extensor digitorum longus (EDL) (Jasper and Tischler 1984). This approach provides an unresponsive muscle in the same limb for evaluating the potential effects of systemic factors. AIB uptake did not differ between weight bearing and unloaded muscles at <10^-5 units insulin/ml. However, at higher insulin, uptake was stimulated moreso in the weight bearing muscles. Therefore, the unloaded muscles exhibited a decreased responsiveness of AIB uptake to insulin.

Original language	English (US)
Pages (from-to)	125-126
Number of pages	2
Journal	Hormone and Metabolic Research
Volume	20
Issue number	2
DOIs	https://doi.org/10.1055/s-2007-1010771
State	Published - 1988

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Endocrinology
Clinical Biochemistry
Biochemistry, medical

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AB - This study considered whether unloading might also alter muscle AIB uptake and its regulation by insulin. Unloading by suspension of the rat hindlimb leads to atrophy of the soleus with little change in mass of the extensor digitorum longus (EDL) (Jasper and Tischler 1984). This approach provides an unresponsive muscle in the same limb for evaluating the potential effects of systemic factors. AIB uptake did not differ between weight bearing and unloaded muscles at <10-5 units insulin/ml. However, at higher insulin, uptake was stimulated moreso in the weight bearing muscles. Therefore, the unloaded muscles exhibited a decreased responsiveness of AIB uptake to insulin.

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Insulin effect on amino acid uptake by unloaded rat hindlimb muscles

Abstract

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