Instrument for the measurement of retinal vessel oxygen saturation

Jonathan Drewes, Matthew Smith, Kurt Denninghoff, Lloyd Hillman

Research output: Contribution to journalConference articlepeer-review

17 Scopus citations


Retinal vessel oxygen saturation has been suggested as a parameter for monitoring a wide range of conditions including occult blood loss and a variety of ophthalmic diseases. We have developed an Eye Oximeter (EOX), that noninvasively measures the oxygen saturation of the blood in individual large retinal vessels using scanning lasers. One-dimensional vessel extinction profiles are obtained at four wavelengths (629, 678, 821 and 899 nm), and the vessel transmittances computed. The oxygen saturation of blood within the vessel is then calculated from the transmittance data. We have performed an in vitro experiment on human blood which demonstrates the calibration of the EOX measurement and validates our oximetry equations. Retinal vessel oxygen saturation was measured in a human subject and found to be 65%O2Sat and 101-102%O2Sat in the veins and arteries on the optic disk. Irregularities in the background measured away from the optic disk resulted in a larger variance in the calculated saturation when compared to measurements made on the disk.

Original languageEnglish (US)
Pages (from-to)114-120
Number of pages7
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - 1999
EventProceedings of the 1999 Ophthalmic Technologies IX - San Jose, CA, USA
Duration: Jan 23 1999Jan 25 1999

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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