TY - JOUR
T1 - Insomnia in alcohol dependent subjects is associated with greater psychosocial problem severity
AU - Chaudhary, Ninad S.
AU - Kampman, Kyle M.
AU - Kranzler, Henry R.
AU - Grandner, Michael A.
AU - Debbarma, Swarnalata
AU - Chakravorty, Subhajit
N1 - Funding Information:
The study was supported by NIH grants R01 AA016553 (K.M.K.); K24 AA013736 (H.R.K.); K23 HL110216 & R21 ES022931 (M.G.) and VA grant IK2CX000855 (S.C.). The content of this publication does not represent the views of the University of Pennsylvania, Department of Veterans Affairs, the United States Government, or any other institution. Results from this study were presented at the Sleep 2014 Annual Meeting in Minneapolis, MN.
Funding Information:
Dr. Kranzler has been a consultant or advisory board member for Alkermes, Lilly, Lundbeck, Otsuka, Pfizer, and Roche and a member of the American Society of Clinical Psychopharmacology's Alcohol Clinical Trials Initiative, supported by AbbVie, Ethypharm, Lilly, Lundbeck, and Pfizer. He has a U.S. patent pending entitled, “Test for Predicting Response to Topiramate and Use of Topiramate.” Dr. Kampman has received support from Titan and Alkermes Pharmaceuticals. Dr. Chakravorty has received research grant support from TEVA pharmaceuticals. Dr. s Chaudhary, Grandner and Debbarma report no conflict of interest.
Publisher Copyright:
© 2015 Published by Elsevier Ltd.
PY - 2015/11/1
Y1 - 2015/11/1
N2 - Introduction: Although psychosocial problems are commonly associated with both alcohol misuse and insomnia, very little is known about the combined effects of insomnia and current alcohol dependence on the severity of psychosocial problems. The present study evaluates whether the co-occurrence of insomnia and alcohol dependence is associated with greater psychosocial problem severity. Methods: Alcohol dependent individuals (N. = 123) were evaluated prior to participation in a placebo-controlled medication trial. The Short Index of Problems (SIP), Addiction Severity Index (ASI), Insomnia Severity Index (ISI), and Time Line Follow Back (TLFB), were used to assess psychosocial, employment, and legal problems; insomnia symptoms; and alcohol consumption, respectively. Bivariate and multivariate analyses were used to evaluate the relations between insomnia and psychosocial problems. Results: Subjects' mean age was 44. years (SD. = 10.3), 83% were male, and their SIP sub-scale scores approximated the median for normative data. A quarter of subjects reported no insomnia; 29% reported mild insomnia; and 45% reported moderate-severe insomnia. The insomnia groups did not differ on alcohol consumption measures. The ISI total score was associated with the SIP total scale score (β. = 0.23, p. = 0.008). Subjects with moderate-severe insomnia had significantly higher scores on the SIP total score, and on the social and impulse control sub-scales, and more ASI employment problems and conflicts with their spouses than others on the ASI. Conclusion: In treatment-seeking alcohol dependent subjects, insomnia may increase alcohol-related adverse psychosocial consequences. Longitudinal studies are needed to clarify the relations between insomnia and psychosocial problems in these subjects.
AB - Introduction: Although psychosocial problems are commonly associated with both alcohol misuse and insomnia, very little is known about the combined effects of insomnia and current alcohol dependence on the severity of psychosocial problems. The present study evaluates whether the co-occurrence of insomnia and alcohol dependence is associated with greater psychosocial problem severity. Methods: Alcohol dependent individuals (N. = 123) were evaluated prior to participation in a placebo-controlled medication trial. The Short Index of Problems (SIP), Addiction Severity Index (ASI), Insomnia Severity Index (ISI), and Time Line Follow Back (TLFB), were used to assess psychosocial, employment, and legal problems; insomnia symptoms; and alcohol consumption, respectively. Bivariate and multivariate analyses were used to evaluate the relations between insomnia and psychosocial problems. Results: Subjects' mean age was 44. years (SD. = 10.3), 83% were male, and their SIP sub-scale scores approximated the median for normative data. A quarter of subjects reported no insomnia; 29% reported mild insomnia; and 45% reported moderate-severe insomnia. The insomnia groups did not differ on alcohol consumption measures. The ISI total score was associated with the SIP total scale score (β. = 0.23, p. = 0.008). Subjects with moderate-severe insomnia had significantly higher scores on the SIP total score, and on the social and impulse control sub-scales, and more ASI employment problems and conflicts with their spouses than others on the ASI. Conclusion: In treatment-seeking alcohol dependent subjects, insomnia may increase alcohol-related adverse psychosocial consequences. Longitudinal studies are needed to clarify the relations between insomnia and psychosocial problems in these subjects.
KW - Alcoholism
KW - Insomnia and sleep and maintenance disorders
KW - Psychosocial factors
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U2 - 10.1016/j.addbeh.2015.06.021
DO - 10.1016/j.addbeh.2015.06.021
M3 - Article
C2 - 26151580
AN - SCOPUS:84934753296
VL - 50
SP - 165
EP - 172
JO - Addictive Behaviors
JF - Addictive Behaviors
SN - 0306-4603
ER -