TY - JOUR
T1 - Insights from natural host-parasite interactions
T2 - The Drosophila model
AU - Keebaugh, Erin S.
AU - Schlenke, Todd A.
N1 - Funding Information:
We thank Z. Lynch for helpful comments. This work was supported by the National Institutes of Health Grants R01 AI081879 to TAS .
PY - 2014/1
Y1 - 2014/1
N2 - Immune responses against opportunistic pathogens have been extensively studied in Drosophila, leading to a detailed map of the genetics behind innate immunity networks including the Toll, Imd, Jak-Stat, and JNK pathways. However, immune mechanisms of other organisms, such as plants, have primarily been investigated using natural pathogens. It was the use of natural pathogens in plant research that revealed the plant R-Avr system, a specialized immune response derived from antagonistic coevolution between plant immune proteins and their natural pathogens' virulence proteins. Thus, we recommend that researchers begin to use natural Drosophila pathogens to identify novel immune strategies that may have arisen through antagonistic coevolution with common natural pathogens. In this review, we address the benefits of using natural pathogens in research, describe the known natural pathogens of Drosophila, and discuss the future prospects for research on natural pathogens of Drosophila.
AB - Immune responses against opportunistic pathogens have been extensively studied in Drosophila, leading to a detailed map of the genetics behind innate immunity networks including the Toll, Imd, Jak-Stat, and JNK pathways. However, immune mechanisms of other organisms, such as plants, have primarily been investigated using natural pathogens. It was the use of natural pathogens in plant research that revealed the plant R-Avr system, a specialized immune response derived from antagonistic coevolution between plant immune proteins and their natural pathogens' virulence proteins. Thus, we recommend that researchers begin to use natural Drosophila pathogens to identify novel immune strategies that may have arisen through antagonistic coevolution with common natural pathogens. In this review, we address the benefits of using natural pathogens in research, describe the known natural pathogens of Drosophila, and discuss the future prospects for research on natural pathogens of Drosophila.
KW - Coevolution
KW - Drosophila immunity
KW - Natural pathogens
UR - http://www.scopus.com/inward/record.url?scp=84886098627&partnerID=8YFLogxK
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U2 - 10.1016/j.dci.2013.06.001
DO - 10.1016/j.dci.2013.06.001
M3 - Article
C2 - 23764256
AN - SCOPUS:84886098627
SN - 0145-305X
VL - 42
SP - 111
EP - 123
JO - Developmental and Comparative Immunology
JF - Developmental and Comparative Immunology
IS - 1
ER -