Insertion sequence duplication in transpositional recombination

Ted A. Weinert; Nancy A. Schaus; Nigel D.F. Grindley

doi:10.1126/science.6314502

Insertion sequence duplication in transpositional recombination

Ted A. Weinert, Nancy A. Schaus, Nigel D.F. Grindley

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Insertion sequences (IS) are discrete segments of DNA that can transpose from one genomic site to another and promote genetic rearrangements. A question that is central to understanding the mechanism of transpositional recombination is whether genetic rearrangements are accompanied by duplication of the IS that promotes them. Analysis of adjacent deletions mediated by IS903 provides the strongest evidence to date than any IS-mediated transpositional recombination can occur by an efficient replicative mechanism.

Original language	English (US)
Pages (from-to)	755-765
Number of pages	11
Journal	Science
Volume	222
Issue number	4625
DOIs	https://doi.org/10.1126/science.6314502
State	Published - 1983
Externally published	Yes

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title = "Insertion sequence duplication in transpositional recombination",

abstract = "Insertion sequences (IS) are discrete segments of DNA that can transpose from one genomic site to another and promote genetic rearrangements. A question that is central to understanding the mechanism of transpositional recombination is whether genetic rearrangements are accompanied by duplication of the IS that promotes them. Analysis of adjacent deletions mediated by IS903 provides the strongest evidence to date than any IS-mediated transpositional recombination can occur by an efficient replicative mechanism.",

author = "Weinert, {Ted A.} and Schaus, {Nancy A.} and Grindley, {Nigel D.F.}",

year = "1983",

doi = "10.1126/science.6314502",

language = "English (US)",

volume = "222",

pages = "755--765",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

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T1 - Insertion sequence duplication in transpositional recombination

AU - Weinert, Ted A.

AU - Schaus, Nancy A.

AU - Grindley, Nigel D.F.

PY - 1983

Y1 - 1983

N2 - Insertion sequences (IS) are discrete segments of DNA that can transpose from one genomic site to another and promote genetic rearrangements. A question that is central to understanding the mechanism of transpositional recombination is whether genetic rearrangements are accompanied by duplication of the IS that promotes them. Analysis of adjacent deletions mediated by IS903 provides the strongest evidence to date than any IS-mediated transpositional recombination can occur by an efficient replicative mechanism.

AB - Insertion sequences (IS) are discrete segments of DNA that can transpose from one genomic site to another and promote genetic rearrangements. A question that is central to understanding the mechanism of transpositional recombination is whether genetic rearrangements are accompanied by duplication of the IS that promotes them. Analysis of adjacent deletions mediated by IS903 provides the strongest evidence to date than any IS-mediated transpositional recombination can occur by an efficient replicative mechanism.

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DO - 10.1126/science.6314502

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ER -

Insertion sequence duplication in transpositional recombination

Abstract

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