TY - JOUR
T1 - Initial genome scan of the NIMH genetics initiative bipolar pedigrees
T2 - Chromosomes 4, 7, 9, 18, 19, 20, and 21q
AU - Detera-Wadleigh, Sevilla D.
AU - Badner, Judith A.
AU - Yoshikawa, Takeo
AU - Sanders, Alan R.
AU - Goldin, Lynn R.
AU - Turner, Gordon
AU - Rolling, Denise Y.
AU - Moses, Tracy
AU - Guroff, Juliet J.
AU - Kazuba, Diane
AU - Maxwell, Mary E.
AU - Edenberg, Howard J.
AU - Foroud, Tatiana
AU - Lahiri, Debomoy
AU - Nurnberger, John I.
AU - Stine, O. Colin
AU - McMahon, Francis
AU - Meyers, Deborah A.
AU - MacKinnon, Dean
AU - Simpson, Sylvia
AU - McInnis, Melvin
AU - DePaulo, J. Raymond
AU - Rice, John
AU - Goate, Alison
AU - Reich, Theodore
AU - Blehar, Mary C.
AU - Gershon, Elliot S.
PY - 1997
Y1 - 1997
N2 - An initial genome scan was performed on 540 individuals from 97 families segregating bipolar disorder, collected through the National Institutes of Mental Health Genetics Initiative. We report here affected-sib-pair (ASP) data on 126 marker loci (≃68,000 genotypes) mapping to chromosomes 4, 7, 9, 18, 19, 20, and 21q, under three affection status models. Modest increases in identical-by-descent (IBD) allele sharing were found at the following loci: D4S2397 and D4S391 (P < 0.05) on 4p, D4S1647 (P < 0.05) on 4q, D7S1802 and D7S1869 (low P = 0.01) on 7p, D9S302 (P = 0.004) on 9q, and D20S604 on 20p and D20S173 on 20q (P ≤ 0.05). In addition, five markers on 7q displayed increased IBD sharing (P = 0.046-0.002). Additional ASP analyses on chromosomes 18 and 21q marker data were performed using disease phenotype models defined previously. On chromosome 18, only D18S40 on 18p and D18S70 on 18q yielded a slight elevation in allele sharing (P = 0.02), implying that the reported linkages in these regions were not confirmed. On chromosome 21q, a cluster of markers within an ≃9 cM interval: D21S1254, D21S65, D21S1440, and D21S1255 exhibited excess allele sharing (P = 0.041-0.008). Multilocus data on overlapping marker quartets, from D21S1265 to D21S1255, which were consistent with increased IBD sharing (P < 0.01, with a low of 0.0009), overlapped a broad interval of excess allele sharing reported previously, increasing support for a susceptibility locus for bipolar disorder on 21q.
AB - An initial genome scan was performed on 540 individuals from 97 families segregating bipolar disorder, collected through the National Institutes of Mental Health Genetics Initiative. We report here affected-sib-pair (ASP) data on 126 marker loci (≃68,000 genotypes) mapping to chromosomes 4, 7, 9, 18, 19, 20, and 21q, under three affection status models. Modest increases in identical-by-descent (IBD) allele sharing were found at the following loci: D4S2397 and D4S391 (P < 0.05) on 4p, D4S1647 (P < 0.05) on 4q, D7S1802 and D7S1869 (low P = 0.01) on 7p, D9S302 (P = 0.004) on 9q, and D20S604 on 20p and D20S173 on 20q (P ≤ 0.05). In addition, five markers on 7q displayed increased IBD sharing (P = 0.046-0.002). Additional ASP analyses on chromosomes 18 and 21q marker data were performed using disease phenotype models defined previously. On chromosome 18, only D18S40 on 18p and D18S70 on 18q yielded a slight elevation in allele sharing (P = 0.02), implying that the reported linkages in these regions were not confirmed. On chromosome 21q, a cluster of markers within an ≃9 cM interval: D21S1254, D21S65, D21S1440, and D21S1255 exhibited excess allele sharing (P = 0.041-0.008). Multilocus data on overlapping marker quartets, from D21S1265 to D21S1255, which were consistent with increased IBD sharing (P < 0.01, with a low of 0.0009), overlapped a broad interval of excess allele sharing reported previously, increasing support for a susceptibility locus for bipolar disorder on 21q.
KW - Bipolar disorder
KW - Bipolar pedigree
KW - Genome scan
KW - Linkage
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UR - http://www.scopus.com/inward/citedby.url?scp=17744410079&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1096-8628(19970531)74:3<254::AID-AJMG4>3.0.CO;2-Q
DO - 10.1002/(SICI)1096-8628(19970531)74:3<254::AID-AJMG4>3.0.CO;2-Q
M3 - Article
C2 - 9184307
AN - SCOPUS:17744410079
SN - 1552-4841
VL - 74
SP - 254
EP - 262
JO - American Journal of Medical Genetics - Neuropsychiatric Genetics
JF - American Journal of Medical Genetics - Neuropsychiatric Genetics
IS - 3
ER -