Initial experience of left bundle branch area pacing using stylet-driven pacing leads: A multicenter study

Jan De Pooter, Emine Ozpak, Simon Calle, Peter Peytchev, Ward Heggermont, Sebastien Marchandise, Frank Provenier, Bart Francois, Wim Anné, Peter Pollet, Cynthia Barbraud, Kris Gillis, Frank Timmermans, Frederic Van Heuverswyn, Roderick Tung, Aurélien Wauters, Jean Benoit le Polain de Waroux

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Background: Left bundle branch area pacing (LBBAP) has been performed exclusively using lumen-less pacing leads (LLL) with fixed helix design. This registry study explores the safety and feasibility of LBBAP using stylet-driven leads (SDL) with extendable helix design in a multicenter patient population. Methods: This study prospectively enrolled consecutive patients who underwent LBBAP for bradycardia pacing or heart failure indications at eight Belgian hospitals. LBBAP was attempted using SDL (Solia S60; Biotronik) delivered through dedicated delivery sheath (Selectra3D). Implant success, complications, procedural, and pacing characteristics were recorded at implant and follow-up. Results: The study enrolled 353 patients (mean age 76 ± 39 years, 43% female). The mean number of implants per center was 25 (range: 5–162). Overall, LBBAP with SDL was successful in 334/353 (94%), varying from 93% to 100% among centers. Pacing response was labeled as left bundle branch pacing in 73%, whereas 27% were labeled as myocardial capture. Mean paced QRS duration and stimulus to left ventricular activation time measured 126 ± 21 ms and 74 ± 17. SDL-LBBAP resulted in low pacing thresholds (0.6 ± 0.4 V at 0.4 ms), which remained stable at 12 months follow-up (0.7 ± 0.3, p =.291). Lead revisions for SDL-LBBAP occurred in 5 (1.4%) patients occurred during a mean follow up of 9 ± 5 months. Five (1.4%) septal coronary artery fistulas and 8 (2%) septal perforations occurred, none of them causing persistent ventricular septal defects. Conclusion: The use of SDL to achieve LBBAP is safe and feasible, characterized by high implant success in low and high volume centers, low complication rates, and stable low pacing thresholds.

Original languageEnglish (US)
Pages (from-to)1540-1549
Number of pages10
JournalJournal of cardiovascular electrophysiology
Issue number7
StatePublished - Jul 2022
Externally publishedYes


  • left bundle branch area pacing
  • left ventricular septal pacing
  • physiologic pacing
  • stylet-driven pacing leads

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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