Inhibitory effects of canthaxanthin on in vitro growth of murine tumor cells

Dennis S. Huang; Olalekan E. Odeleye; Ronald R. Watson

doi:10.1016/0304-3835(92)90233-L

Inhibitory effects of canthaxanthin on in vitro growth of murine tumor cells

Dennis S. Huang, Olalekan E. Odeleye, Ronald R. Watson

Health Promotion Sciences

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

The antitumorigenic effects of carotenoids, in addition to their immuno-enhancing effects, may occur by their direct action on growing tumor cells. To test this hypothesis the direct inhibitory effect of various concentrations of canthaxanthin (CX; 4,4′-diketo-β-carotene), a non-provitamin A carotenoid, was tested on the in vitro growth of, B16F10 melanomas and PYB6 fibrosarcoma and murine non-transformed NIH-3T3 (ATCC CRL 1658) cells. At concentrations of 1 × 10^-8 M up to 1 × 10^-4 M, CX significantly reduced the overall number of tumor cells. The greatest inhibition was observed at a CX concentration of 1 × 10^-4 M after 72 h and 96 h of incubation. However, CX had no inhibitory effect on the growth of the non-transformed NIH-3T3 cell line; rather it significantly enhanced growth of this cell line (P < 0.05) after 96 h of incubation. Thus, the inhibitory action of CX on growing tumor cells appears to be due to its direct actions on tumor cells and not via its conversion to vitamin A or its immuno-enhancing effects.

Original language	English (US)
Pages (from-to)	209-213
Number of pages	5
Journal	Cancer Letters
Volume	65
Issue number	3
DOIs	https://doi.org/10.1016/0304-3835(92)90233-L
State	Published - Aug 31 1992

Keywords

canthaxanthin
inhibition
transformed and non-transformed cells
tumor growth

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/0304-3835(92)90233-L

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title = "Inhibitory effects of canthaxanthin on in vitro growth of murine tumor cells",

abstract = "The antitumorigenic effects of carotenoids, in addition to their immuno-enhancing effects, may occur by their direct action on growing tumor cells. To test this hypothesis the direct inhibitory effect of various concentrations of canthaxanthin (CX; 4,4′-diketo-β-carotene), a non-provitamin A carotenoid, was tested on the in vitro growth of, B16F10 melanomas and PYB6 fibrosarcoma and murine non-transformed NIH-3T3 (ATCC CRL 1658) cells. At concentrations of 1 × 10-8 M up to 1 × 10-4 M, CX significantly reduced the overall number of tumor cells. The greatest inhibition was observed at a CX concentration of 1 × 10-4 M after 72 h and 96 h of incubation. However, CX had no inhibitory effect on the growth of the non-transformed NIH-3T3 cell line; rather it significantly enhanced growth of this cell line (P < 0.05) after 96 h of incubation. Thus, the inhibitory action of CX on growing tumor cells appears to be due to its direct actions on tumor cells and not via its conversion to vitamin A or its immuno-enhancing effects.",

keywords = "canthaxanthin, inhibition, transformed and non-transformed cells, tumor growth",

author = "Huang, {Dennis S.} and Odeleye, {Olalekan E.} and Watson, {Ronald R.}",

note = "Funding Information: This work was supportedb y a grant from Wallace Genetic Foundation, Inc. to R.R. Watson.S pecialt hankst o Drs. E. Urger, T. Fritz,T . Gordon and M.C. Lopez for excellent consultation.",

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AU - Watson, Ronald R.

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N2 - The antitumorigenic effects of carotenoids, in addition to their immuno-enhancing effects, may occur by their direct action on growing tumor cells. To test this hypothesis the direct inhibitory effect of various concentrations of canthaxanthin (CX; 4,4′-diketo-β-carotene), a non-provitamin A carotenoid, was tested on the in vitro growth of, B16F10 melanomas and PYB6 fibrosarcoma and murine non-transformed NIH-3T3 (ATCC CRL 1658) cells. At concentrations of 1 × 10-8 M up to 1 × 10-4 M, CX significantly reduced the overall number of tumor cells. The greatest inhibition was observed at a CX concentration of 1 × 10-4 M after 72 h and 96 h of incubation. However, CX had no inhibitory effect on the growth of the non-transformed NIH-3T3 cell line; rather it significantly enhanced growth of this cell line (P < 0.05) after 96 h of incubation. Thus, the inhibitory action of CX on growing tumor cells appears to be due to its direct actions on tumor cells and not via its conversion to vitamin A or its immuno-enhancing effects.

AB - The antitumorigenic effects of carotenoids, in addition to their immuno-enhancing effects, may occur by their direct action on growing tumor cells. To test this hypothesis the direct inhibitory effect of various concentrations of canthaxanthin (CX; 4,4′-diketo-β-carotene), a non-provitamin A carotenoid, was tested on the in vitro growth of, B16F10 melanomas and PYB6 fibrosarcoma and murine non-transformed NIH-3T3 (ATCC CRL 1658) cells. At concentrations of 1 × 10-8 M up to 1 × 10-4 M, CX significantly reduced the overall number of tumor cells. The greatest inhibition was observed at a CX concentration of 1 × 10-4 M after 72 h and 96 h of incubation. However, CX had no inhibitory effect on the growth of the non-transformed NIH-3T3 cell line; rather it significantly enhanced growth of this cell line (P < 0.05) after 96 h of incubation. Thus, the inhibitory action of CX on growing tumor cells appears to be due to its direct actions on tumor cells and not via its conversion to vitamin A or its immuno-enhancing effects.

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Inhibitory effects of canthaxanthin on in vitro growth of murine tumor cells

Abstract

Keywords

ASJC Scopus subject areas

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