Inhibition of lipid mediator biosynthesis in human inflammatory cells by BIRM 270

T. P. Parks, A. F. Hoffman, C. A. Homon, A. G. Graham, E. S. Lazer, F. H. Chilton, P. Borgeat, D. Raible, E. Schulman, D. A. Bass, P. R. Farina

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

BIRM 270 was developed as a potent and enantioselective inhibitor of LTB4 biosynthesis by human neutrophils, and was also found to inhibit LTC4 production by human eosinophils and lung mast cells. BIRM 270 inhibited LTB4 synthesis in neutrophils by preventing arachidonate release from membrane phospholipids, and over the same concentration range, inhibited PAF biosynthesis. BIRM 270 did not directly inhibit acylhydrolases which have been implicated in eicosanoid and PAF biosynthesis, suggesting an indirect mode of action.

Original languageEnglish (US)
Pages (from-to)139-146
Number of pages8
JournalAgents and Actions
Volume46
Issue numberSUPPL.
DOIs
StatePublished - 1995
Externally publishedYes

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)

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