Inhibition of immune responses in vitro by specific antiserums to Ia antigens

Jeffrey A. Frelinger; John E. Niederhuber; Donald C. Shreffler

doi:10.1126/science.1118728

Inhibition of immune responses in vitro by specific antiserums to Ia antigens

Jeffrey A. Frelinger
, John E. Niederhuber
, Donald C. Shreffler

Immunobiology

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

Mouse antiserums prepared against la antigens, which are products of I (immune reponse) region genes of the H-2 complex, can inhibit both primary (immunoglobulin M) and secondary (immunoglobulin G) immune responses in vitro by mouse spleen cultures to heterologous erythrocytes. Antiserums directed specifically at products of either the H-2K or H-2D loci have no effect on this response.

Original language	English (US)
Pages (from-to)	268-270
Number of pages	3
Journal	Science
Volume	188
Issue number	4185
DOIs	https://doi.org/10.1126/science.1118728
State	Published - 1975

ASJC Scopus subject areas

General

Access to Document

10.1126/science.1118728

Cite this

@article{ffd2e02592984be0b4c0843519838d9f,

title = "Inhibition of immune responses in vitro by specific antiserums to Ia antigens",

abstract = "Mouse antiserums prepared against la antigens, which are products of I (immune reponse) region genes of the H-2 complex, can inhibit both primary (immunoglobulin M) and secondary (immunoglobulin G) immune responses in vitro by mouse spleen cultures to heterologous erythrocytes. Antiserums directed specifically at products of either the H-2K or H-2D loci have no effect on this response.",

author = "Frelinger, \{Jeffrey A.\} and Niederhuber, \{John E.\} and Shreffler, \{Donald C.\}",

year = "1975",

doi = "10.1126/science.1118728",

language = "English (US)",

volume = "188",

pages = "268--270",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "4185",

}

TY - JOUR

T1 - Inhibition of immune responses in vitro by specific antiserums to Ia antigens

AU - Frelinger, Jeffrey A.

AU - Niederhuber, John E.

AU - Shreffler, Donald C.

PY - 1975

Y1 - 1975

N2 - Mouse antiserums prepared against la antigens, which are products of I (immune reponse) region genes of the H-2 complex, can inhibit both primary (immunoglobulin M) and secondary (immunoglobulin G) immune responses in vitro by mouse spleen cultures to heterologous erythrocytes. Antiserums directed specifically at products of either the H-2K or H-2D loci have no effect on this response.

AB - Mouse antiserums prepared against la antigens, which are products of I (immune reponse) region genes of the H-2 complex, can inhibit both primary (immunoglobulin M) and secondary (immunoglobulin G) immune responses in vitro by mouse spleen cultures to heterologous erythrocytes. Antiserums directed specifically at products of either the H-2K or H-2D loci have no effect on this response.

UR - https://www.scopus.com/pages/publications/0016789876

UR - https://www.scopus.com/pages/publications/0016789876#tab=citedBy

U2 - 10.1126/science.1118728

DO - 10.1126/science.1118728

M3 - Article

C2 - 1118728

AN - SCOPUS:0016789876

SN - 0036-8075

VL - 188

SP - 268

EP - 270

JO - Science

JF - Science

IS - 4185

ER -

Inhibition of immune responses in vitro by specific antiserums to Ia antigens

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this