@article{45e0e079234d49b5895ad39eb0f53a99,
title = "Inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity",
abstract = "Impaired glucose homeostasis and energy balance are integral to the pathophysiology of diabetes and obesity. Here we show that administration of a glycine transporter 1 (GlyT1) inhibitor, or molecular GlyT1 knockdown, in the dorsal vagal complex (DVC) suppresses glucose production, increases glucose tolerance and reduces food intake and body weight gain in healthy, obese and diabetic rats. These findings provide proof of concept that GlyT1 inhibition in the brain improves glucose and energy homeostasis. Considering the clinical safety and efficacy of GlyT1 inhibitors in raising glycine levels in clinical trials for schizophrenia, we propose that GlyT1 inhibitors have the potential to be repurposed as a treatment of both obesity and diabetes.",
author = "Yue, {Jessica T.Y.} and Abraham, {Mona A.} and Bauer, {Paige V.} and Lapierre, {Mary P.} and Peili Wang and Duca, {Frank A.} and Filippi, {Beatrice M.} and Owen Chan and Lam, {Tony K.T.}",
note = "Funding Information: This work was supported by a Canadian Institutes of Health Research (CIHR) Foundation Grant to T.K.T.L. (FDN-143204) and the Yale Diabetes Research Centre (P30 DK45735). J.T.Y.Y. was supported by post-doctoral fellowships from the CIHR and the Canadian Diabetes Association. M.A.A. was supported by a CIHR Doctoral Research Scholarship. P.V.B. was supported by an Ontario Graduate Scholarship and a Banting and Best Diabetes Centre Graduate Studentship. M.P.L. was supported by a CIHR Graduate Scholarship. F.A.D. was a Banting Fellow. T.K.T.L. holds the John Kitson McIvor (1915-1942) Endowed Chair in Diabetes Research and the Canada Research Chair in Obesity at the Toronto General Hospital Research Institute and the University of Toronto. Publisher Copyright: {\textcopyright} 2016 The Author(s).",
year = "2016",
month = nov,
day = "22",
doi = "10.1038/ncomms13501",
language = "English (US)",
volume = "7",
journal = "Nature communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
}