Inhibition of gastrin release by somatostatin in vitro

J. R. Hayes; D. G. Johnson; D. Koerker; R. H. Williams

doi:10.1210/endo-96-6-1374

Inhibition of gastrin release by somatostatin in vitro

J. R. Hayes, D. G. Johnson, D. Koerker, R. H. Williams

Medicine

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56 Scopus citations

Abstract

An in vitro system which uses perifused pieces from the antrum of rat stomach has been used to study the effect of dihydrosomatostatin on gastrin release. The gastrin concentration in fractions of the perfusate was measured by radioimmunoassay. Dihydrosomatostatin (2 × 10⁻⁷M) had no effect on basal gastrin levels but virtually abolished the biphasic response seen with arginine stimulation. The study demonstrates close functional similarities between G cells and pancreatic islet cells.

Original language	English (US)
Pages (from-to)	1374-1376
Number of pages	3
Journal	Endocrinology
Volume	96
Issue number	6
DOIs	https://doi.org/10.1210/endo-96-6-1374
State	Published - Jun 1975

ASJC Scopus subject areas

Endocrinology

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AB - An in vitro system which uses perifused pieces from the antrum of rat stomach has been used to study the effect of dihydrosomatostatin on gastrin release. The gastrin concentration in fractions of the perfusate was measured by radioimmunoassay. Dihydrosomatostatin (2 × 10−7M) had no effect on basal gastrin levels but virtually abolished the biphasic response seen with arginine stimulation. The study demonstrates close functional similarities between G cells and pancreatic islet cells.

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Inhibition of gastrin release by somatostatin in vitro

Abstract

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