Inhibition of ethanol induced ethane exhalation by carcinogenic pretreatment of rats 12 months earlier

Janos Szebeni; Cleamond D. Eskelson; Siraj I. Mufti; Ronald R. Watson; I. Glenn Sipes

doi:10.1016/0024-3205(86)90113-X

Inhibition of ethanol induced ethane exhalation by carcinogenic pretreatment of rats 12 months earlier

Janos Szebeni, Cleamond D. Eskelson, Siraj I. Mufti, Ronald R. Watson, I. Glenn Sipes

Health Promotion Sciences

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Abstract

The exhalation of ethane was used as a measure of in vivo lipid peroxidation in rats treated with the hepatocarcinogen diethylnitrosamine followed by 2-acetylaminofluorene (AAF), and carbon tetrachloride, and subsequently fed a liquid diet containing 7 % ethanol for 12 months. The other groups consisted of animals treated with methylbenzylnitrosamine (MBN), an esophageal carcinogen, or non-carcinogen pretreated animals with or without 7% ethanol feeding. Ethane production was increased in rats consuming ethanol irrespective of their pretreatment with MBN. In sharp contrast, the ethanol-induced increase of ethane production was absent in rats given the hepatocarcinogenic regime. Our results strengthen recent observations indicating decreased susceptibility of tumor cells to lipid peroxidation. In addition, they confirm the debated concept that there is increased lipid peroxidation following ethanol consumption.

Original language	English (US)
Pages (from-to)	2587-2591
Number of pages	5
Journal	Life Sciences
Volume	39
Issue number	26
DOIs	https://doi.org/10.1016/0024-3205(86)90113-X
State	Published - Dec 29 1986

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/0024-3205(86)90113-X

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@article{0193cd502d13434f8fc19eae143177de,

title = "Inhibition of ethanol induced ethane exhalation by carcinogenic pretreatment of rats 12 months earlier",

abstract = "The exhalation of ethane was used as a measure of in vivo lipid peroxidation in rats treated with the hepatocarcinogen diethylnitrosamine followed by 2-acetylaminofluorene (AAF), and carbon tetrachloride, and subsequently fed a liquid diet containing 7 % ethanol for 12 months. The other groups consisted of animals treated with methylbenzylnitrosamine (MBN), an esophageal carcinogen, or non-carcinogen pretreated animals with or without 7% ethanol feeding. Ethane production was increased in rats consuming ethanol irrespective of their pretreatment with MBN. In sharp contrast, the ethanol-induced increase of ethane production was absent in rats given the hepatocarcinogenic regime. Our results strengthen recent observations indicating decreased susceptibility of tumor cells to lipid peroxidation. In addition, they confirm the debated concept that there is increased lipid peroxidation following ethanol consumption.",

author = "Janos Szebeni and Eskelson, {Cleamond D.} and Mufti, {Siraj I.} and Watson, {Ronald R.} and {Glenn Sipes}, I.",

note = "Funding Information: We apprecmate the encouragement of Dr. B. Hartmann and Dr. A. Vuturo. The support by Ph~ Beta Psi Sorority, US Navy Contract No. 244-84-D-1509 and NIEHS Grant No. ES03438 are acknowledged.",

year = "1986",

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day = "29",

doi = "10.1016/0024-3205(86)90113-X",

language = "English (US)",

volume = "39",

pages = "2587--2591",

journal = "Life Sciences",

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T1 - Inhibition of ethanol induced ethane exhalation by carcinogenic pretreatment of rats 12 months earlier

AU - Szebeni, Janos

AU - Eskelson, Cleamond D.

AU - Mufti, Siraj I.

AU - Watson, Ronald R.

AU - Glenn Sipes, I.

N1 - Funding Information: We apprecmate the encouragement of Dr. B. Hartmann and Dr. A. Vuturo. The support by Ph~ Beta Psi Sorority, US Navy Contract No. 244-84-D-1509 and NIEHS Grant No. ES03438 are acknowledged.

PY - 1986/12/29

Y1 - 1986/12/29

N2 - The exhalation of ethane was used as a measure of in vivo lipid peroxidation in rats treated with the hepatocarcinogen diethylnitrosamine followed by 2-acetylaminofluorene (AAF), and carbon tetrachloride, and subsequently fed a liquid diet containing 7 % ethanol for 12 months. The other groups consisted of animals treated with methylbenzylnitrosamine (MBN), an esophageal carcinogen, or non-carcinogen pretreated animals with or without 7% ethanol feeding. Ethane production was increased in rats consuming ethanol irrespective of their pretreatment with MBN. In sharp contrast, the ethanol-induced increase of ethane production was absent in rats given the hepatocarcinogenic regime. Our results strengthen recent observations indicating decreased susceptibility of tumor cells to lipid peroxidation. In addition, they confirm the debated concept that there is increased lipid peroxidation following ethanol consumption.

AB - The exhalation of ethane was used as a measure of in vivo lipid peroxidation in rats treated with the hepatocarcinogen diethylnitrosamine followed by 2-acetylaminofluorene (AAF), and carbon tetrachloride, and subsequently fed a liquid diet containing 7 % ethanol for 12 months. The other groups consisted of animals treated with methylbenzylnitrosamine (MBN), an esophageal carcinogen, or non-carcinogen pretreated animals with or without 7% ethanol feeding. Ethane production was increased in rats consuming ethanol irrespective of their pretreatment with MBN. In sharp contrast, the ethanol-induced increase of ethane production was absent in rats given the hepatocarcinogenic regime. Our results strengthen recent observations indicating decreased susceptibility of tumor cells to lipid peroxidation. In addition, they confirm the debated concept that there is increased lipid peroxidation following ethanol consumption.

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DO - 10.1016/0024-3205(86)90113-X

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AN - SCOPUS:0023018098

SN - 0024-3205

VL - 39

SP - 2587

EP - 2591

JO - Life Sciences

JF - Life Sciences

IS - 26

ER -

Inhibition of ethanol induced ethane exhalation by carcinogenic pretreatment of rats 12 months earlier

Abstract

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