Inhibition of DNA transcription elongation and unwinding by bis-PNA

L. Bastide, G. Villani, P. Nielsen, P. E. Boehmer, B. Lebleu

Research output: Contribution to journalArticlepeer-review


The possibility to arrest transcription elongation by bis-PNA has been investigated. No arrest of transcription has been obtained in intact cells at variance with the data observed with purified RNA-polymerases. In keeping with these data a purified DNA-helicase (UL9) cannot be fully inhibited by such complexes.

Original languageEnglish (US)
Pages (from-to)1669-1671
Number of pages3
JournalNucleosides and Nucleotides
Issue number6-7
StatePublished - 1999

ASJC Scopus subject areas

  • Biochemistry
  • Genetics


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