TY - JOUR
T1 - Inhibition of different phases of coccidioides immitis by human neutrophils or hydrogen peroxide
AU - Galgiani, John N.
N1 - Funding Information:
Received for publication 27 June 1985, and in revised form 12 September 1985. This work was supported by the Veterans Administration and was presented at the American Federation of Clinical Research Annual Meeting, Washington, D.C., 3-6 May 1985. The technical assistance of Rosemary Z. Hayden and Kris O. Dugger was an invaluable contribution to the conduct of these studies. Informed consent was obtained from all participants, and the guidelines of the University of Arizona Health Sciences Center Committee on Human Studies in Research were followed in the conduct of this work. Please address requests for reprints to Dr. John N. Galgiani, Medical Service (111), VAMedical Center, Tucson, Arizona 85723.
PY - 1986/2
Y1 - 1986/2
N2 - As arthroconidia of Coccidioides immitis transform into spherules, the fungal particles progressively become more resistant to the inhibitory effects of human polymorphonuclear leukocytes (PMNLs) as measured by PMNL inhibition of fungal incorporation of Nacetylglucosamine. Similar changes werenoted when leucine incorporation was measured. When H2O2, at a concentration of 2.0 mM, was substituted for PMNLs, an equivalent inhibition of arthroconidia was produced and, as with PMNL effects, was lost with spherule maturation. The results from these studies indicate that C immitis may evade natural inhibition by PMNLs by transformation into the spherule phase.
AB - As arthroconidia of Coccidioides immitis transform into spherules, the fungal particles progressively become more resistant to the inhibitory effects of human polymorphonuclear leukocytes (PMNLs) as measured by PMNL inhibition of fungal incorporation of Nacetylglucosamine. Similar changes werenoted when leucine incorporation was measured. When H2O2, at a concentration of 2.0 mM, was substituted for PMNLs, an equivalent inhibition of arthroconidia was produced and, as with PMNL effects, was lost with spherule maturation. The results from these studies indicate that C immitis may evade natural inhibition by PMNLs by transformation into the spherule phase.
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U2 - 10.1093/infdis/153.2.217
DO - 10.1093/infdis/153.2.217
M3 - Article
C2 - 3944479
AN - SCOPUS:0022620609
SN - 0022-1899
VL - 153
SP - 217
EP - 222
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 2
ER -