Inhibition of aspartic proteinases by propart peptides of human procathepsin D and chicken pepsinogen

M. Fusek; M. Mareš; J. Vágner; Z. Voburka; M. Baudyš

doi:10.1016/0014-5793(91)80040-A

Inhibition of aspartic proteinases by propart peptides of human procathepsin D and chicken pepsinogen

M. Fusek, M. Mareš, J. Vágner, Z. Voburka, M. Baudyš

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

Two propart peptides of aspartic proteinases. the propart peptide of chicken pepsin and human cathepsin D, respectively, were investigated from the point of view of their inhibitory activity for a set of aspartic proteinases. These peptides display a very broad inhibitory spectrum. The strongest inhibition was observed for pepsin A-like proteinases where propart peptides can be used as titrants of active enzymes.

Original language	English (US)
Pages (from-to)	160-162
Number of pages	3
Journal	FEBS Letters
Volume	287
Issue number	1-2
DOIs	https://doi.org/10.1016/0014-5793(91)80040-A
State	Published - Aug 5 1991
Externally published	Yes

Keywords

Aspartic proteinase
Chicken pepsinogen: Inhibition
Human procathepsin D
Propart peptide
Zymogen activation

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/0014-5793(91)80040-A

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title = "Inhibition of aspartic proteinases by propart peptides of human procathepsin D and chicken pepsinogen",

abstract = "Two propart peptides of aspartic proteinases. the propart peptide of chicken pepsin and human cathepsin D, respectively, were investigated from the point of view of their inhibitory activity for a set of aspartic proteinases. These peptides display a very broad inhibitory spectrum. The strongest inhibition was observed for pepsin A-like proteinases where propart peptides can be used as titrants of active enzymes.",

keywords = "Aspartic proteinase, Chicken pepsinogen: Inhibition, Human procathepsin D, Propart peptide, Zymogen activation",

author = "M. Fusek and M. Mare{\v s} and J. V{\'a}gner and Z. Voburka and M. Baudy{\v s}",

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doi = "10.1016/0014-5793(91)80040-A",

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T1 - Inhibition of aspartic proteinases by propart peptides of human procathepsin D and chicken pepsinogen

AU - Fusek, M.

AU - Mareš, M.

AU - Vágner, J.

AU - Voburka, Z.

AU - Baudyš, M.

PY - 1991/8/5

Y1 - 1991/8/5

N2 - Two propart peptides of aspartic proteinases. the propart peptide of chicken pepsin and human cathepsin D, respectively, were investigated from the point of view of their inhibitory activity for a set of aspartic proteinases. These peptides display a very broad inhibitory spectrum. The strongest inhibition was observed for pepsin A-like proteinases where propart peptides can be used as titrants of active enzymes.

AB - Two propart peptides of aspartic proteinases. the propart peptide of chicken pepsin and human cathepsin D, respectively, were investigated from the point of view of their inhibitory activity for a set of aspartic proteinases. These peptides display a very broad inhibitory spectrum. The strongest inhibition was observed for pepsin A-like proteinases where propart peptides can be used as titrants of active enzymes.

KW - Aspartic proteinase

KW - Chicken pepsinogen: Inhibition

KW - Human procathepsin D

KW - Propart peptide

KW - Zymogen activation

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JO - FEBS Letters

JF - FEBS Letters

IS - 1-2

ER -

Inhibition of aspartic proteinases by propart peptides of human procathepsin D and chicken pepsinogen

Abstract

Keywords

ASJC Scopus subject areas

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