Inheritance of immunoglobulin E: Genetic model fitting

S. J. Hasstedt; D. A. Meyers; D. G. Marsh

doi:10.1002/ajmg.1320140110

Inheritance of immunoglobulin E: Genetic model fitting

S. J. Hasstedt, D. A. Meyers, D. G. Marsh

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Total serum immunoglobulin E (IgE) concentration was measured on 316 members of five pedigrees selected through breast cancer probands. Sex- and age-adjusted natural logarithm-transformed IgE level was not found to differ between individuals with breast cancer or with cancer of any site and other relatives. Likelihoods of the polygenic and of one-locus, two-allele major gene and mixed models were computed. The analysis provided evidence for the presence of a polygenic component in the determination of IgE; it did not show evidence of a major gene effect.

Original language	English (US)
Pages (from-to)	61-66
Number of pages	6
Journal	American journal of medical genetics
Volume	14
Issue number	1
DOIs	https://doi.org/10.1002/ajmg.1320140110
State	Published - 1983
Externally published	Yes

ASJC Scopus subject areas

Genetics(clinical)

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abstract = "Total serum immunoglobulin E (IgE) concentration was measured on 316 members of five pedigrees selected through breast cancer probands. Sex- and age-adjusted natural logarithm-transformed IgE level was not found to differ between individuals with breast cancer or with cancer of any site and other relatives. Likelihoods of the polygenic and of one-locus, two-allele major gene and mixed models were computed. The analysis provided evidence for the presence of a polygenic component in the determination of IgE; it did not show evidence of a major gene effect.",

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year = "1983",

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T2 - Genetic model fitting

AU - Hasstedt, S. J.

AU - Meyers, D. A.

AU - Marsh, D. G.

PY - 1983

Y1 - 1983

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AB - Total serum immunoglobulin E (IgE) concentration was measured on 316 members of five pedigrees selected through breast cancer probands. Sex- and age-adjusted natural logarithm-transformed IgE level was not found to differ between individuals with breast cancer or with cancer of any site and other relatives. Likelihoods of the polygenic and of one-locus, two-allele major gene and mixed models were computed. The analysis provided evidence for the presence of a polygenic component in the determination of IgE; it did not show evidence of a major gene effect.

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ER -

Inheritance of immunoglobulin E: Genetic model fitting

Abstract

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