Inheritance of immunoglobulin E: Genetic model fitting

S. J. Hasstedt, D. A. Meyers, D. G. Marsh

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

Total serum immunoglobulin E (IgE) concentration was measured on 316 members of five pedigrees selected through breast cancer probands. Sex- and age-adjusted natural logarithm-transformed IgE level was not found to differ between individuals with breast cancer or with cancer of any site and other relatives. Likelihoods of the polygenic and of one-locus, two-allele major gene and mixed models were computed. The analysis provided evidence for the presence of a polygenic component in the determination of IgE; it did not show evidence of a major gene effect.

Original languageEnglish (US)
Pages (from-to)61-66
Number of pages6
JournalAmerican journal of medical genetics
Volume14
Issue number1
DOIs
StatePublished - 1983
Externally publishedYes

ASJC Scopus subject areas

  • Genetics(clinical)

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