Ingibirovanie katepsina G i élastazy granulotsitov cheloveka mnozhestvennymi formami soevogo ingibitora tipa Baumana-Birk.

N. I. Larionova; I. P. Gladysheva; T. V. Tikhonova; N. F. Kazanskaia

Ingibirovanie katepsina G i élastazy granulotsitov cheloveka mnozhestvennymi formami soevogo ingibitora tipa Baumana-Birk.

Translated title of the contribution: Inhibition of cathepsin G and elastase from human granulocytes by multiple forms of the Bowman-Birk type of soy inhibitor

N. I. Larionova
, I. P. Gladysheva
, T. V. Tikhonova
, N. F. Kazanskaia

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

A classical soybean inhibitor (Bowman-Birk inhibitor, BBI 2-IV) and two high molecular weight glycine-enriched inhibitors of the same type (3-II and 4-II) have been isolated, purified to homogeneity and characterized. All of the BBI isoforms have been found to effectively inhibit cathepsin G and human granulocyte elastase. The constants for leucocyte cathepsin G inhibition by classical BBI 2-IV (Ki = 1.2 x 10(-9) M) and high molecular mass BBI 3-II (Ki = 8.0 x 10(-8) M) as well as for leucocyte elastase inhibition by high molecular mass BBI 3-II (Ki = 1.1 x 10(-7) M) have been determined.

Translated title of the contribution	Inhibition of cathepsin G and elastase from human granulocytes by multiple forms of the Bowman-Birk type of soy inhibitor
Original language	Russian
Pages (from-to)	1437-1444
Number of pages	8
Journal	Biokhimiya
Volume	58
Issue number	9
State	Published - Aug 1993
Externally published	Yes

ASJC Scopus subject areas

General Chemistry

Cite this

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title = "Ingibirovanie katepsina G i {\'e}lastazy granulotsitov cheloveka mnozhestvennymi formami soevogo ingibitora tipa Baumana-Birk.",

abstract = "A classical soybean inhibitor (Bowman-Birk inhibitor, BBI 2-IV) and two high molecular weight glycine-enriched inhibitors of the same type (3-II and 4-II) have been isolated, purified to homogeneity and characterized. All of the BBI isoforms have been found to effectively inhibit cathepsin G and human granulocyte elastase. The constants for leucocyte cathepsin G inhibition by classical BBI 2-IV (Ki = 1.2 x 10(-9) M) and high molecular mass BBI 3-II (Ki = 8.0 x 10(-8) M) as well as for leucocyte elastase inhibition by high molecular mass BBI 3-II (Ki = 1.1 x 10(-7) M) have been determined.",

author = "Larionova, \{N. I.\} and Gladysheva, \{I. P.\} and Tikhonova, \{T. V.\} and Kazanskaia, \{N. F.\}",

year = "1993",

month = aug,

language = "Russian",

volume = "58",

pages = "1437--1444",

journal = "Biokhimiya",

issn = "0320-9725",

publisher = "Nauka, Moscow",

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T1 - Ingibirovanie katepsina G i élastazy granulotsitov cheloveka mnozhestvennymi formami soevogo ingibitora tipa Baumana-Birk.

AU - Larionova, N. I.

AU - Gladysheva, I. P.

AU - Tikhonova, T. V.

AU - Kazanskaia, N. F.

PY - 1993/8

Y1 - 1993/8

N2 - A classical soybean inhibitor (Bowman-Birk inhibitor, BBI 2-IV) and two high molecular weight glycine-enriched inhibitors of the same type (3-II and 4-II) have been isolated, purified to homogeneity and characterized. All of the BBI isoforms have been found to effectively inhibit cathepsin G and human granulocyte elastase. The constants for leucocyte cathepsin G inhibition by classical BBI 2-IV (Ki = 1.2 x 10(-9) M) and high molecular mass BBI 3-II (Ki = 8.0 x 10(-8) M) as well as for leucocyte elastase inhibition by high molecular mass BBI 3-II (Ki = 1.1 x 10(-7) M) have been determined.

AB - A classical soybean inhibitor (Bowman-Birk inhibitor, BBI 2-IV) and two high molecular weight glycine-enriched inhibitors of the same type (3-II and 4-II) have been isolated, purified to homogeneity and characterized. All of the BBI isoforms have been found to effectively inhibit cathepsin G and human granulocyte elastase. The constants for leucocyte cathepsin G inhibition by classical BBI 2-IV (Ki = 1.2 x 10(-9) M) and high molecular mass BBI 3-II (Ki = 8.0 x 10(-8) M) as well as for leucocyte elastase inhibition by high molecular mass BBI 3-II (Ki = 1.1 x 10(-7) M) have been determined.

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M3 - Article

C2 - 8218567

AN - SCOPUS:0027645257

SN - 0320-9725

VL - 58

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EP - 1444

JO - Biokhimiya

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IS - 9

ER -

Ingibirovanie katepsina G i élastazy granulotsitov cheloveka mnozhestvennymi formami soevogo ingibitora tipa Baumana-Birk.

Abstract

ASJC Scopus subject areas

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