Influence of the Metabolism on Myeloid Cell Functions in Cancers: Clinical Perspectives

Thomas Boyer, Céline Blaye, Nicolas Larmonier, Charlotte Domblides

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Tumor metabolism plays a crucial role in sustaining tumorigenesis. There have been increasing reports regarding the role of tumor metabolism in the control of immune cell functions, generating a potent immunosuppressive contexture that can lead to immune escape. The metabolic reprogramming of tumor cells and the immune escape are two major hallmarks of cancer, with several instances of crosstalk between them. In this paper, we review the effects of tumor metabolism on immune cells, focusing on myeloid cells due to their important role in tumorigenesis and immunosuppression from the early stages of the disease. We also discuss ways to target this specific crosstalk in cancer patients.

Original languageEnglish (US)
Article number554
Issue number3
StatePublished - Feb 1 2022


  • Cancer
  • Immunomodulation
  • Immunotherapy
  • Macrophages
  • Metabolism
  • Myeloid cells
  • Myeloid-derived suppressive cells
  • Therapeutic strategies

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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