TY - JOUR
T1 - Influence of the carboxymethyl chitosan anti-adhesion solution on the TGF-β1 in a postoperative peritoneal adhesion rat
AU - Zheng, Zengjuan
AU - Zhang, Weifen
AU - Sun, Weiqing
AU - Li, Xiaojian
AU - Duan, Jinghua
AU - Cui, Juanjuan
AU - Feng, Zhanqin
AU - Mansour, Heidi M.
N1 - Funding Information:
Acknowledgments The authors are grateful for the generous financial support from Shandong Provincial Natural Science Foundation, China (Y2008F15; ZR2012CM025) for grant support; The Scientific and Technological Development Project of Shandong Province (2012YD18063); Shandong Province Higher Educational Science, Technology Program (J11LF67) and the Health Department of Shan-dong Province (2011HZ115) and Weifang Science and Technology Bureau Project (201232112).
PY - 2013/11
Y1 - 2013/11
N2 - The aim of this paper was to investigate the effect of carboxymethyl chitosan anti-adhesion solution on prevention of postsurgical adhesion. Forty adult male Wistar rats were randomly divided into three groups: 0.9 % normal saline solution (group A), hyaluronic acid gels (group B) and carboxymethyl chitosan anti-adhesion solution (group C). The animals were treated with normal saline, hyaluronic acid gels or carboxymethyl chitosan anti-adhesion solution at the time of surgery. After 2 or 3 weeks, the degree of adhesions and histological effects were determined. The adhesions in groups B and C were significantly decreased, and the levels of TGF-β1 and hydroxyproline in group C were significantly lower than that in group A (P < 0.05). The histopathology in group C showed fewer inflammatory cells and fibroblasts. Carboxymethyl chitosan anti-adhesion solution can effectively prevent postoperative adhesion which is a promising drug delivery system in the context of postsurgical anti-adhesion.
AB - The aim of this paper was to investigate the effect of carboxymethyl chitosan anti-adhesion solution on prevention of postsurgical adhesion. Forty adult male Wistar rats were randomly divided into three groups: 0.9 % normal saline solution (group A), hyaluronic acid gels (group B) and carboxymethyl chitosan anti-adhesion solution (group C). The animals were treated with normal saline, hyaluronic acid gels or carboxymethyl chitosan anti-adhesion solution at the time of surgery. After 2 or 3 weeks, the degree of adhesions and histological effects were determined. The adhesions in groups B and C were significantly decreased, and the levels of TGF-β1 and hydroxyproline in group C were significantly lower than that in group A (P < 0.05). The histopathology in group C showed fewer inflammatory cells and fibroblasts. Carboxymethyl chitosan anti-adhesion solution can effectively prevent postoperative adhesion which is a promising drug delivery system in the context of postsurgical anti-adhesion.
UR - https://www.scopus.com/pages/publications/84887190069
UR - https://www.scopus.com/pages/publications/84887190069#tab=citedBy
U2 - 10.1007/s10856-013-4981-7
DO - 10.1007/s10856-013-4981-7
M3 - Article
C2 - 23820936
AN - SCOPUS:84887190069
SN - 0957-4530
VL - 24
SP - 2549
EP - 2559
JO - Journal of Materials Science: Materials in Medicine
JF - Journal of Materials Science: Materials in Medicine
IS - 11
ER -