Influence of the carboxymethyl chitosan anti-adhesion solution on the TGF-β1 in a postoperative peritoneal adhesion rat

Zengjuan Zheng; Weifen Zhang; Weiqing Sun; Xiaojian Li; Jinghua Duan; Juanjuan Cui; Zhanqin Feng; Heidi M. Mansour

doi:10.1007/s10856-013-4981-7

Influence of the carboxymethyl chitosan anti-adhesion solution on the TGF-β1 in a postoperative peritoneal adhesion rat

Zengjuan Zheng, Weifen Zhang, Weiqing Sun, Xiaojian Li, Jinghua Duan, Juanjuan Cui, Zhanqin Feng, Heidi M. Mansour

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

The aim of this paper was to investigate the effect of carboxymethyl chitosan anti-adhesion solution on prevention of postsurgical adhesion. Forty adult male Wistar rats were randomly divided into three groups: 0.9 % normal saline solution (group A), hyaluronic acid gels (group B) and carboxymethyl chitosan anti-adhesion solution (group C). The animals were treated with normal saline, hyaluronic acid gels or carboxymethyl chitosan anti-adhesion solution at the time of surgery. After 2 or 3 weeks, the degree of adhesions and histological effects were determined. The adhesions in groups B and C were significantly decreased, and the levels of TGF-β₁ and hydroxyproline in group C were significantly lower than that in group A (P < 0.05). The histopathology in group C showed fewer inflammatory cells and fibroblasts. Carboxymethyl chitosan anti-adhesion solution can effectively prevent postoperative adhesion which is a promising drug delivery system in the context of postsurgical anti-adhesion.

Original language	English (US)
Pages (from-to)	2549-2559
Number of pages	11
Journal	Journal of Materials Science: Materials in Medicine
Volume	24
Issue number	11
DOIs	https://doi.org/10.1007/s10856-013-4981-7
State	Published - Nov 2013

ASJC Scopus subject areas

Biophysics
Bioengineering
Biomaterials
Biomedical Engineering

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title = "Influence of the carboxymethyl chitosan anti-adhesion solution on the TGF-β1 in a postoperative peritoneal adhesion rat",

abstract = "The aim of this paper was to investigate the effect of carboxymethyl chitosan anti-adhesion solution on prevention of postsurgical adhesion. Forty adult male Wistar rats were randomly divided into three groups: 0.9 % normal saline solution (group A), hyaluronic acid gels (group B) and carboxymethyl chitosan anti-adhesion solution (group C). The animals were treated with normal saline, hyaluronic acid gels or carboxymethyl chitosan anti-adhesion solution at the time of surgery. After 2 or 3 weeks, the degree of adhesions and histological effects were determined. The adhesions in groups B and C were significantly decreased, and the levels of TGF-β1 and hydroxyproline in group C were significantly lower than that in group A (P < 0.05). The histopathology in group C showed fewer inflammatory cells and fibroblasts. Carboxymethyl chitosan anti-adhesion solution can effectively prevent postoperative adhesion which is a promising drug delivery system in the context of postsurgical anti-adhesion.",

author = "Zengjuan Zheng and Weifen Zhang and Weiqing Sun and Xiaojian Li and Jinghua Duan and Juanjuan Cui and Zhanqin Feng and Mansour, {Heidi M.}",

note = "Funding Information: Acknowledgments The authors are grateful for the generous financial support from Shandong Provincial Natural Science Foundation, China (Y2008F15; ZR2012CM025) for grant support; The Scientific and Technological Development Project of Shandong Province (2012YD18063); Shandong Province Higher Educational Science, Technology Program (J11LF67) and the Health Department of Shan-dong Province (2011HZ115) and Weifang Science and Technology Bureau Project (201232112).",

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AU - Zheng, Zengjuan

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AU - Li, Xiaojian

AU - Duan, Jinghua

AU - Cui, Juanjuan

AU - Feng, Zhanqin

AU - Mansour, Heidi M.

N1 - Funding Information: Acknowledgments The authors are grateful for the generous financial support from Shandong Provincial Natural Science Foundation, China (Y2008F15; ZR2012CM025) for grant support; The Scientific and Technological Development Project of Shandong Province (2012YD18063); Shandong Province Higher Educational Science, Technology Program (J11LF67) and the Health Department of Shan-dong Province (2011HZ115) and Weifang Science and Technology Bureau Project (201232112).

PY - 2013/11

Y1 - 2013/11

N2 - The aim of this paper was to investigate the effect of carboxymethyl chitosan anti-adhesion solution on prevention of postsurgical adhesion. Forty adult male Wistar rats were randomly divided into three groups: 0.9 % normal saline solution (group A), hyaluronic acid gels (group B) and carboxymethyl chitosan anti-adhesion solution (group C). The animals were treated with normal saline, hyaluronic acid gels or carboxymethyl chitosan anti-adhesion solution at the time of surgery. After 2 or 3 weeks, the degree of adhesions and histological effects were determined. The adhesions in groups B and C were significantly decreased, and the levels of TGF-β1 and hydroxyproline in group C were significantly lower than that in group A (P < 0.05). The histopathology in group C showed fewer inflammatory cells and fibroblasts. Carboxymethyl chitosan anti-adhesion solution can effectively prevent postoperative adhesion which is a promising drug delivery system in the context of postsurgical anti-adhesion.

AB - The aim of this paper was to investigate the effect of carboxymethyl chitosan anti-adhesion solution on prevention of postsurgical adhesion. Forty adult male Wistar rats were randomly divided into three groups: 0.9 % normal saline solution (group A), hyaluronic acid gels (group B) and carboxymethyl chitosan anti-adhesion solution (group C). The animals were treated with normal saline, hyaluronic acid gels or carboxymethyl chitosan anti-adhesion solution at the time of surgery. After 2 or 3 weeks, the degree of adhesions and histological effects were determined. The adhesions in groups B and C were significantly decreased, and the levels of TGF-β1 and hydroxyproline in group C were significantly lower than that in group A (P < 0.05). The histopathology in group C showed fewer inflammatory cells and fibroblasts. Carboxymethyl chitosan anti-adhesion solution can effectively prevent postoperative adhesion which is a promising drug delivery system in the context of postsurgical anti-adhesion.

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Influence of the carboxymethyl chitosan anti-adhesion solution on the TGF-β1 in a postoperative peritoneal adhesion rat

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