Abstract
An expression having a basic cubic form was derived to describe the in vitro release of drugs from slow‐release tablets formulated with a homogeneous insoluble matrix. While the rate of drug release varies with tablet shape, rate constants that are independent of shape are included in the expression. By comparison with previously published work, it was shown that the rate constants may be described in terms of the physicochemical properties of the tablet constituents and the degree of compression. Therefore, it should be possible to evaluate the rate constants for model formulations and then, using the pertinent release expression, to predict the rate of drug release from tablets having identical compositions but varying widely in shape and size.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 725-732 |
| Number of pages | 8 |
| Journal | Journal of pharmaceutical sciences |
| Volume | 63 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 1974 |
| Externally published | Yes |
Keywords
- Drug release from matrix tablets—relationship between release and tablet shape, theory, equations
- Tablets, slow release—in vitro release from homogeneous insoluble matrix, theory and equations relating release and tablet shape
- Timed‐release tablets—in vitro slow release from homogeneous insoluble matrix, effect of tablet shape, theory, equations
ASJC Scopus subject areas
- Pharmaceutical Science