Influence of magnesium ion on human ventricular defibrillation after aortocoronary bypass surgery

Bernice R. Hecker, Carol L. Lake, Irving L. Kron, Robert M. Mentzer, Ivan K. Crosby, Stanton P. Nolan, Richard S. Crampton

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


The administration of magnesium ion (Mg++) has been reported to defibrillate the ventricles and to decrease the incidence of arrhythmias after cardiopulmonary bypass. In a prospective study of 76 randomly selected patients undergoing coronary artery bypass grafting, patients received either no Mg++, 0.25 mEq/kg of Mg++ during cardiopulmonary bypass with the aorta clamped, or 0.375 mEq/kg of Mg++ before cardiopulmonary bypass. Spontaneous resumption of a cardiac rhythm or spontaneous defibrillation during reperfusion was not significantly affected by Mg++ administration. However, the number of shocks to initial and to sustained defibrillation and the energy required for the last direct-current shock was greatest in patients who received Mg++ before bypass and in those whose plasma Mg++ was greater than 2.26 mg/dl. Thus, the administration of Mg++ may have adverse effects on the heart if intraoperative plasma Mg++ exceeds 2.26 mg/dl.

Original languageEnglish (US)
Pages (from-to)61-64
Number of pages4
JournalThe American Journal of Cardiology
Issue number1
StatePublished - Jan 1 1985

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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