Influence of H-2 haplotypes on poly IC induction of xanthine oxidase and poly IC induced decreases in P-450 mediated enzyme activities

A. Koizumi; L. Hasegawa; K. E. Rodgers; D. Ellefson; R. L. Walford; T. Imamura

doi:10.1016/0006-291X(86)90272-X

Influence of H-2 haplotypes on poly IC induction of xanthine oxidase and poly IC induced decreases in P-450 mediated enzyme activities

A. Koizumi
, L. Hasegawa
, K. E. Rodgers
, D. Ellefson
, R. L. Walford
, T. Imamura

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Polyriboinosinic - polyribocytidylic acid (poly IC), a potent interferon inducer, induced xanthine oxidase 24 hours after treatment with 5 mg/kg ip to different degrees among four H-2 congenic mice (P < 0.05): B10 (H-2b: 236 ± 27% of the control value) > B10.RIII (H-2r: 171 ± 29%) = B10.F (H-2n: 161 ± 12%) > B10.BR (H-2K: 136 ± 15%). Aryl hydrocarbon hydroxylase (AHH) activity showed an inverse correlation with inducibility of xanthine oxidase (r = -0.71, P < 0.01). However, there were no significant changes in activities of heme pool associated enzymes, such as catalase, tryptophan pyrrolase and d-aminolevulinic acid synthase in these mice. H-2 haplotype seems to have an influence on poly IC induction of xanthine oxidase thereby causing a decrease in AHH.

Original language	English (US)
Pages (from-to)	246-253
Number of pages	8
Journal	Biochemical and Biophysical Research Communications
Volume	138
Issue number	1
DOIs	https://doi.org/10.1016/0006-291X(86)90272-X
State	Published - Jul 16 1986
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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title = "Influence of H-2 haplotypes on poly IC induction of xanthine oxidase and poly IC induced decreases in P-450 mediated enzyme activities",

abstract = "Polyriboinosinic - polyribocytidylic acid (poly IC), a potent interferon inducer, induced xanthine oxidase 24 hours after treatment with 5 mg/kg ip to different degrees among four H-2 congenic mice (P < 0.05): B10 (H-2b: 236 ± 27\% of the control value) > B10.RIII (H-2r: 171 ± 29\%) = B10.F (H-2n: 161 ± 12\%) > B10.BR (H-2K: 136 ± 15\%). Aryl hydrocarbon hydroxylase (AHH) activity showed an inverse correlation with inducibility of xanthine oxidase (r = -0.71, P < 0.01). However, there were no significant changes in activities of heme pool associated enzymes, such as catalase, tryptophan pyrrolase and d-aminolevulinic acid synthase in these mice. H-2 haplotype seems to have an influence on poly IC induction of xanthine oxidase thereby causing a decrease in AHH.",

author = "A. Koizumi and L. Hasegawa and Rodgers, \{K. E.\} and D. Ellefson and Walford, \{R. L.\} and T. Imamura",

year = "1986",

month = jul,

day = "16",

doi = "10.1016/0006-291X(86)90272-X",

language = "English (US)",

volume = "138",

pages = "246--253",

journal = "Biochemical and Biophysical Research Communications",

issn = "0006-291X",

publisher = "Elsevier B.V.",

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TY - JOUR

T1 - Influence of H-2 haplotypes on poly IC induction of xanthine oxidase and poly IC induced decreases in P-450 mediated enzyme activities

AU - Koizumi, A.

AU - Hasegawa, L.

AU - Rodgers, K. E.

AU - Ellefson, D.

AU - Walford, R. L.

AU - Imamura, T.

PY - 1986/7/16

Y1 - 1986/7/16

N2 - Polyriboinosinic - polyribocytidylic acid (poly IC), a potent interferon inducer, induced xanthine oxidase 24 hours after treatment with 5 mg/kg ip to different degrees among four H-2 congenic mice (P < 0.05): B10 (H-2b: 236 ± 27% of the control value) > B10.RIII (H-2r: 171 ± 29%) = B10.F (H-2n: 161 ± 12%) > B10.BR (H-2K: 136 ± 15%). Aryl hydrocarbon hydroxylase (AHH) activity showed an inverse correlation with inducibility of xanthine oxidase (r = -0.71, P < 0.01). However, there were no significant changes in activities of heme pool associated enzymes, such as catalase, tryptophan pyrrolase and d-aminolevulinic acid synthase in these mice. H-2 haplotype seems to have an influence on poly IC induction of xanthine oxidase thereby causing a decrease in AHH.

AB - Polyriboinosinic - polyribocytidylic acid (poly IC), a potent interferon inducer, induced xanthine oxidase 24 hours after treatment with 5 mg/kg ip to different degrees among four H-2 congenic mice (P < 0.05): B10 (H-2b: 236 ± 27% of the control value) > B10.RIII (H-2r: 171 ± 29%) = B10.F (H-2n: 161 ± 12%) > B10.BR (H-2K: 136 ± 15%). Aryl hydrocarbon hydroxylase (AHH) activity showed an inverse correlation with inducibility of xanthine oxidase (r = -0.71, P < 0.01). However, there were no significant changes in activities of heme pool associated enzymes, such as catalase, tryptophan pyrrolase and d-aminolevulinic acid synthase in these mice. H-2 haplotype seems to have an influence on poly IC induction of xanthine oxidase thereby causing a decrease in AHH.

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UR - https://www.scopus.com/pages/publications/0022493964#tab=citedBy

U2 - 10.1016/0006-291X(86)90272-X

DO - 10.1016/0006-291X(86)90272-X

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C2 - 3755596

AN - SCOPUS:0022493964

SN - 0006-291X

VL - 138

SP - 246

EP - 253

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 1

ER -

Influence of H-2 haplotypes on poly IC induction of xanthine oxidase and poly IC induced decreases in P-450 mediated enzyme activities

Abstract

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