Polyriboinosinic - polyribocytidylic acid (poly IC), a potent interferon inducer, induced xanthine oxidase 24 hours after treatment with 5 mg/kg ip to different degrees among four H-2 congenic mice (P < 0.05): B10 (H-2b: 236 ± 27% of the control value) > B10.RIII (H-2r: 171 ± 29%) = B10.F (H-2n: 161 ± 12%) > B10.BR (H-2K: 136 ± 15%). Aryl hydrocarbon hydroxylase (AHH) activity showed an inverse correlation with inducibility of xanthine oxidase (r = -0.71, P < 0.01). However, there were no significant changes in activities of heme pool associated enzymes, such as catalase, tryptophan pyrrolase and d-aminolevulinic acid synthase in these mice. H-2 haplotype seems to have an influence on poly IC induction of xanthine oxidase thereby causing a decrease in AHH.
|Original language||English (US)|
|Number of pages||8|
|Journal||Biochemical and Biophysical Research Communications|
|State||Published - Jul 16 1986|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology