Influence of enteral feedings on phenytoin sodium absorption from capsules

L. Y. Nishimura; E. P. Armstrong; P. M. Plezia; R. P. Iacono

doi:10.1177/106002808802200205

Influence of enteral feedings on phenytoin sodium absorption from capsules

L. Y. Nishimura, E. P. Armstrong, P. M. Plezia, R. P. Iacono

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

The influence of enteral feeding (with Ensure) on the absorption of phenytoin sodium from capsules was studied. Six healthy and adult volunteers were given a single dose of phenytoin capsules 400 mg po on two occasions. Blood specimens were collected for 48 hours after each dose. In a randomized, crossover fashion, each subject completed the following two phases: (1) phenytoin without enteral feedings, and (2) concomitant enteral feedings before phenytoin and continued at 100 ml/h for ten hours. The areas under the concentration versus time curves from 0-48 hours (AUC_0-48) were not significantly different between the two phases (p > 0.5). The percent relative bioavailability of phenytoin with enteral feedings was 101.7 percent. This study suggests that enteral feedings do not affect the serum concentrations of phenytoin after a single dose given in capsule form.

Original language	English (US)
Pages (from-to)	130-133
Number of pages	4
Journal	Drug Intelligence and Clinical Pharmacy
Volume	22
Issue number	2
DOIs	https://doi.org/10.1177/106002808802200205
State	Published - 1988
Externally published	Yes

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
Pharmacology (medical)

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title = "Influence of enteral feedings on phenytoin sodium absorption from capsules",

abstract = "The influence of enteral feeding (with Ensure) on the absorption of phenytoin sodium from capsules was studied. Six healthy and adult volunteers were given a single dose of phenytoin capsules 400 mg po on two occasions. Blood specimens were collected for 48 hours after each dose. In a randomized, crossover fashion, each subject completed the following two phases: (1) phenytoin without enteral feedings, and (2) concomitant enteral feedings before phenytoin and continued at 100 ml/h for ten hours. The areas under the concentration versus time curves from 0-48 hours (AUC0-48) were not significantly different between the two phases (p > 0.5). The percent relative bioavailability of phenytoin with enteral feedings was 101.7 percent. This study suggests that enteral feedings do not affect the serum concentrations of phenytoin after a single dose given in capsule form.",

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T1 - Influence of enteral feedings on phenytoin sodium absorption from capsules

AU - Nishimura, L. Y.

AU - Armstrong, E. P.

AU - Plezia, P. M.

AU - Iacono, R. P.

PY - 1988

Y1 - 1988

N2 - The influence of enteral feeding (with Ensure) on the absorption of phenytoin sodium from capsules was studied. Six healthy and adult volunteers were given a single dose of phenytoin capsules 400 mg po on two occasions. Blood specimens were collected for 48 hours after each dose. In a randomized, crossover fashion, each subject completed the following two phases: (1) phenytoin without enteral feedings, and (2) concomitant enteral feedings before phenytoin and continued at 100 ml/h for ten hours. The areas under the concentration versus time curves from 0-48 hours (AUC0-48) were not significantly different between the two phases (p > 0.5). The percent relative bioavailability of phenytoin with enteral feedings was 101.7 percent. This study suggests that enteral feedings do not affect the serum concentrations of phenytoin after a single dose given in capsule form.

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Influence of enteral feedings on phenytoin sodium absorption from capsules

Abstract

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