Abstract
Objective: To investigate the influence of bFGF on the proliferation of hypoxia culture indothelial cells, and explore the mechanism of bFGF promoting revascilarization under hypoxia. Methods: When cell reached 70%-80% confluence, then added bFGF and was cultured in hyproxia. Flow cybometry was performed to analyse the effect of bFGF on cell cycle. Results: We found that bFGF could improve the PI value and SPF value of hyproxic cultured endothelial cells by flow cybometry analysis. Conclusion: bFGF can reverse the effect of hypoxia on the proliferation capacity of endothelial cells and make an increasment to SPF value and PI value.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 299-300+315 |
| Journal | Medical Journal of Wuhan University |
| Volume | 23 |
| Issue number | 4 |
| State | Published - Oct 2002 |
| Externally published | Yes |
Keywords
- bFGF
- Endothelial cell
- Hyproxic culture
- Proliferation
ASJC Scopus subject areas
- General Medicine
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