Influence of background lung characteristics on nodule detection with computed tomography

Boning Li, Taylor B. Smith, Kingshuk R. Choudhury, Brian Harrawood, Lukas Ebner, Justus E. Roos, Geoffrey D. Rubin

Research output: Contribution to journalArticlepeer-review


We sought to characterize local lung complexity in chest computed tomography (CT) and to characterize its impact on the detectability of pulmonary nodules. Forty volumetric chest CT scans were created by embedding between three and five simulated 5-mm lung nodules into one of three volumetric chest CT datasets. Thirteen radiologists evaluated 157 nodules, resulting in 2041 detection opportunities. Analyzing the substrate CT data prior to nodule insertion, 14 image features were measured within a region around each nodule location. A generalized linear mixed-effects statistical model was fit to the data to verify the contribution of each metric on detectability. The model was tuned for simplicity, interpretability, and generalizability using stepwise regression applied to the primary features and their interactions. We found that variables corresponding to each of five categories (local structural distractors, local intensity, global context, local vascularity, and contiguity with structural distractors) were significant (p < 0.01) factors in a standardized model. Moreover, reader-specific models conveyed significant differences among readers with significant distraction (missed detections) influenced by local intensity- versus local-structural characteristics being mutually exclusive. Readers with significant local intensity distraction (n = 10) detected substantially fewer lung nodules than those who were significantly distracted by local structure (n = 2), 46.1% versus 65.3% mean nodules detected, respectively.

Original languageEnglish (US)
Article number022409
JournalJournal of Medical Imaging
Issue number2
StatePublished - Mar 1 2020
Externally publishedYes


  • Anatomical complexity
  • Computed tomography
  • Generalized linear statistical model
  • Image perception
  • Interobserver variability
  • Lung nodule detectability
  • Observer performance

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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