TY - JOUR
T1 - Inflectional morphology in primary progressive aphasia
T2 - An elicited production study
AU - Wilson, Stephen M.
AU - Brandt, Temre H.
AU - Henry, Maya L.
AU - Babiak, Miranda
AU - Ogar, Jennifer M.
AU - Salli, Chelsey
AU - Wilson, Lisa
AU - Peralta, Karen
AU - Miller, Bruce L.
AU - Gorno-Tempini, Maria Luisa
N1 - Funding Information:
This research was supported in part by National Institutes of Health (NIDCD R03 DC010878 to SMW, NINDS R01 NS050915 to MLGT, NIA P50 AG03006 to BLM, NIA P01 AG019724 to BLM); University of Arizona; State of California (DHS 04-35516); Alzheimer’s Disease Research Center of California (03-75271 DHS/ADP/ARCC); Larry L. Hillblom Foundation; John Douglas French Alzheimer’s Foundation; Koret Family Foundation; McBean Family Foundation; and University of Arizona. We thank Kevin Shapiro and Alfonso Caramazza for sharing their stimuli, Reva Wilheim and Jessica DeLeon for collecting control data, Alisa Berg, Ashley Chavez, Adam Gendreau, Lua Hedayati, Rachel Mueller, Leah Swanson, and Lauren Zimmerman for assistance with transcription, Karalyn Patterson and one other reviewer for constructive comments, all of the members of the UCSF Memory and Aging Center who contributed to patient evaluation and care, and all of the patients, caregivers and volunteers for their participation in our research.
PY - 2014/9
Y1 - 2014/9
N2 - Inflectional morphology lies at the intersection of phonology, syntax and the lexicon, three language domains that are differentially impacted in the three main variants of primary progressive aphasia (PPA). To characterize spared and impaired aspects of inflectional morphology in PPA, we elicited inflectional morphemes in 48 individuals with PPA and 13 healthy age-matched controls. We varied the factors of regularity, frequency, word class, and lexicality, and used voxel-based morphometry to identify brain regions where atrophy was predictive of deficits on particular conditions. All three PPA variants showed deficits in inflectional morphology, with the specific nature of the deficits dependent on the anatomical and linguistic features of each variant. Deficits in inflecting low-frequency irregular words were associated with semantic PPA, with lexical/semantic deficits, and with left temporal atrophy. Deficits in inflecting pseudowords were associated with non-fluent/agrammatic and logopenic variants, with phonological deficits, and with left frontal and parietal atrophy.
AB - Inflectional morphology lies at the intersection of phonology, syntax and the lexicon, three language domains that are differentially impacted in the three main variants of primary progressive aphasia (PPA). To characterize spared and impaired aspects of inflectional morphology in PPA, we elicited inflectional morphemes in 48 individuals with PPA and 13 healthy age-matched controls. We varied the factors of regularity, frequency, word class, and lexicality, and used voxel-based morphometry to identify brain regions where atrophy was predictive of deficits on particular conditions. All three PPA variants showed deficits in inflectional morphology, with the specific nature of the deficits dependent on the anatomical and linguistic features of each variant. Deficits in inflecting low-frequency irregular words were associated with semantic PPA, with lexical/semantic deficits, and with left temporal atrophy. Deficits in inflecting pseudowords were associated with non-fluent/agrammatic and logopenic variants, with phonological deficits, and with left frontal and parietal atrophy.
KW - Inflectional morphology
KW - Primary progressive aphasia
KW - Semantic dementia
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U2 - 10.1016/j.bandl.2014.07.001
DO - 10.1016/j.bandl.2014.07.001
M3 - Article
C2 - 25129631
AN - SCOPUS:84906731782
SN - 0093-934X
VL - 136
SP - 58
EP - 68
JO - Brain and Language
JF - Brain and Language
ER -