Infections Complicating Orthotopic Liver Transplantation: A Study Emphasizing Graft-Related Septicemia

Gerhard P.J. Schröter, Manfred Hoelscher, Charles W. Putnam, Kendrick A. Porter, John F. Hansbrough, Thomas E. Starzl

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

In 93 recipients of 102 orthotopic liver homografts, the incidence of bacteremia or fungemia exceeded 70%. The graft itself was usually an entry site for systemic infection after both immunologic and nonimmunologic parenchymal injury, especially if there was defective biliary drainage. The role of the homograft itself as the special infectious risk factor has prompted increased use of defunctionalized jejunal Roux limbs to reduce graft contamination. It has also stimulated very aggressive postoperative diagnostic efforts to rule out remedial mechanical complications of the transplant.

Original languageEnglish (US)
Pages (from-to)1337-1347
Number of pages11
JournalArchives of Surgery
Volume111
Issue number12
DOIs
StatePublished - Dec 1976
Externally publishedYes

ASJC Scopus subject areas

  • Surgery

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