Infections Complicating Orthotopic Liver Transplantation: A Study Emphasizing Graft-Related Septicemia

Gerhard P.J. Schröter; Manfred Hoelscher; Charles W. Putnam; Kendrick A. Porter; John F. Hansbrough; Thomas E. Starzl

doi:10.1001/archsurg.1976.01360300027004

Infections Complicating Orthotopic Liver Transplantation: A Study Emphasizing Graft-Related Septicemia

Gerhard P.J. Schröter, Manfred Hoelscher, Charles W. Putnam, Kendrick A. Porter, John F. Hansbrough, Thomas E. Starzl

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

In 93 recipients of 102 orthotopic liver homografts, the incidence of bacteremia or fungemia exceeded 70%. The graft itself was usually an entry site for systemic infection after both immunologic and nonimmunologic parenchymal injury, especially if there was defective biliary drainage. The role of the homograft itself as the special infectious risk factor has prompted increased use of defunctionalized jejunal Roux limbs to reduce graft contamination. It has also stimulated very aggressive postoperative diagnostic efforts to rule out remedial mechanical complications of the transplant.

Original language	English (US)
Pages (from-to)	1337-1347
Number of pages	11
Journal	Archives of Surgery
Volume	111
Issue number	12
DOIs	https://doi.org/10.1001/archsurg.1976.01360300027004
State	Published - Dec 1976
Externally published	Yes

ASJC Scopus subject areas

Surgery

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10.1001/archsurg.1976.01360300027004

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title = "Infections Complicating Orthotopic Liver Transplantation: A Study Emphasizing Graft-Related Septicemia",

abstract = "In 93 recipients of 102 orthotopic liver homografts, the incidence of bacteremia or fungemia exceeded 70%. The graft itself was usually an entry site for systemic infection after both immunologic and nonimmunologic parenchymal injury, especially if there was defective biliary drainage. The role of the homograft itself as the special infectious risk factor has prompted increased use of defunctionalized jejunal Roux limbs to reduce graft contamination. It has also stimulated very aggressive postoperative diagnostic efforts to rule out remedial mechanical complications of the transplant.",

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year = "1976",

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doi = "10.1001/archsurg.1976.01360300027004",

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AU - Hoelscher, Manfred

AU - Putnam, Charles W.

AU - Porter, Kendrick A.

AU - Hansbrough, John F.

AU - Starzl, Thomas E.

PY - 1976/12

Y1 - 1976/12

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AB - In 93 recipients of 102 orthotopic liver homografts, the incidence of bacteremia or fungemia exceeded 70%. The graft itself was usually an entry site for systemic infection after both immunologic and nonimmunologic parenchymal injury, especially if there was defective biliary drainage. The role of the homograft itself as the special infectious risk factor has prompted increased use of defunctionalized jejunal Roux limbs to reduce graft contamination. It has also stimulated very aggressive postoperative diagnostic efforts to rule out remedial mechanical complications of the transplant.

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Infections Complicating Orthotopic Liver Transplantation: A Study Emphasizing Graft-Related Septicemia

Abstract

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