Induction of the proto-oncogene c-jun by angiotensin II

A. J. Naftilan, G. K. Gilliland, C. S. Eldridge, A. S. Kraft

Research output: Contribution to journalArticlepeer-review

155 Scopus citations


Angiotensin (Ang) II causes hypertrophy of rat aortic smooth muscle cells in culture and results in the rapid activation of c-fos. This study demonstrated that Ang II also activated c-jun and, in addition, could activate the AP-1 enhancer element. These data add support for a role of Ang II as an important mediator of vascular smooth muscle cell growth.

Original languageEnglish (US)
Pages (from-to)5536-5540
Number of pages5
JournalMolecular and cellular biology
Issue number10
StatePublished - 1990

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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