Inducing myointimal hyperplasia versus atherosclerosis in mice: An introduction of two valid models

Mandy Stubbendorff, Xiaoqin Hua, Tobias Deuse, Ziad Ali, Hermann Reichenspurner, Lars Maegdefessel, Robert C. Robbins, Sonja Schrepfer

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Various in vivo laboratory rodent models for the induction of artery stenosis have been established to mimic diseases that include arterial plaque formation and stenosis, as observed for example in ischemic heart disease. Two highly reproducible mouse models - both resulting in artery stenosis but each underlying a different pathway of development - are introduced here. The models represent the two most common causes of artery stenosis; namely one mouse model for each myointimal hyperplasia, and atherosclerosis are shown. To induce myointimal hyperplasia, a balloon catheter injury of the abdominal aorta is performed. For the development of atherosclerotic plaque, the ApoE -/- mouse model in combination with western fatty diet is used. Different model-adapted options for the measurement and evaluation of the results are named and described in this manuscript. The introduction and comparison of these two models provides information for scientists to choose the appropriate artery stenosis model in accordance to the scientific question asked.

Original languageEnglish (US)
Article numbere51459
JournalJournal of Visualized Experiments
Issue number87
StatePublished - May 14 2014
Externally publishedYes


  • Analysis
  • ApoE -/-
  • Atherosclerosis
  • Balloon injury
  • Coronary stenosis
  • Denudation model
  • Issue 87
  • Medicine
  • Mice
  • Myointimal hyperplasia
  • Neointima
  • Vascular diseases
  • Western diet

ASJC Scopus subject areas

  • Neuroscience(all)
  • Chemical Engineering(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)


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