Inducible nitric oxide synthase (inos) and heart failure

Bo Yang, Douglas F. Larson, Ronald R. Watson

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations


Over the last 15 years, the nitric oxide (NO) literature has experienced exponential growth (from 7 papers on endogenous NO in 1987 to over 45,000 in 2002). The link between inducible nitric oxide synthase (iNOS) and heart failure is accepted as an important association and is opening potential therapeutic avenues for the treatment of heart failure. Most literature suggests a deleterious effect of iNOS on heart function in dilated cardiomyopathy, ischemic cardiomyopathy, septic shock, cardiac allograft rejection, and viral and autoimmune myocarditis, although some controversial arguments continue.

Original languageEnglish (US)
Title of host publicationNutrition and Heart Disease
Subtitle of host publicationCausation and Prevention
PublisherCRC Press
Number of pages18
ISBN (Electronic)9780203507629
ISBN (Print)9780849316746
StatePublished - Jan 1 2003

ASJC Scopus subject areas

  • General Medicine


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