TY - JOUR
T1 - Independent Contributions of Dorsolateral Prefrontal Structure and Function to Working Memory in Healthy Older Adults
AU - Evangelista, Nicole D.
AU - O'Shea, Andrew
AU - Kraft, Jessica N.
AU - Hausman, Hanna K.
AU - Boutzoukas, Emanuel M.
AU - Nissim, Nicole R.
AU - Albizu, Alejandro
AU - Hardcastle, Cheshire
AU - Van Etten, Emily J.
AU - Bharadwaj, Pradyumna K.
AU - Smith, Samantha G.
AU - Song, Hyun
AU - Hishaw, Georg A
AU - Dekosky, Steven
AU - Wu, Samuel
AU - Porges, Eric
AU - Alexander, Gene E.
AU - Marsiske, Michael
AU - Cohen, Ronald
AU - Woods, Adam J.
N1 - Publisher Copyright:
© 2020 The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: [email protected].
PY - 2021/3/1
Y1 - 2021/3/1
N2 - Age-related differences in dorsolateral prefrontal cortex (DLPFC) structure and function have each been linked to working memory. However, few studies have integrated multimodal imaging to simultaneously investigate relationships among structure, function, and cognition. We aimed to clarify how specifically DLPFC structure and function contribute to working memory in healthy older adults. In total, 138 participants aged 65-88 underwent 3 T neuroimaging and were divided into higher and lower groups based on a median split of in-scanner n-back task performance. Three a priori spherical DLPFC regions of interest (ROIs) were used to quantify blood-oxygen-level-dependent (BOLD) signal and FreeSurfer-derived surface area, cortical thickness, and white matter volume. Binary logistic regressions adjusting for age, sex, education, and scanner type revealed that greater left and right DLPFC BOLD signal predicted the probability of higher performing group membership (P values<.05). Binary logistic regressions also adjusting for total intracranial volume revealed left DLPFC surface area that significantly predicted the probability of being in the higher performing group (P = 0.017). The left DLPFC BOLD signal and surface area were not significantly associated and did not significantly interact to predict group membership (P values>.05). Importantly, this suggests BOLD signal and surface area may independently contribute to working memory performance in healthy older adults.
AB - Age-related differences in dorsolateral prefrontal cortex (DLPFC) structure and function have each been linked to working memory. However, few studies have integrated multimodal imaging to simultaneously investigate relationships among structure, function, and cognition. We aimed to clarify how specifically DLPFC structure and function contribute to working memory in healthy older adults. In total, 138 participants aged 65-88 underwent 3 T neuroimaging and were divided into higher and lower groups based on a median split of in-scanner n-back task performance. Three a priori spherical DLPFC regions of interest (ROIs) were used to quantify blood-oxygen-level-dependent (BOLD) signal and FreeSurfer-derived surface area, cortical thickness, and white matter volume. Binary logistic regressions adjusting for age, sex, education, and scanner type revealed that greater left and right DLPFC BOLD signal predicted the probability of higher performing group membership (P values<.05). Binary logistic regressions also adjusting for total intracranial volume revealed left DLPFC surface area that significantly predicted the probability of being in the higher performing group (P = 0.017). The left DLPFC BOLD signal and surface area were not significantly associated and did not significantly interact to predict group membership (P values>.05). Importantly, this suggests BOLD signal and surface area may independently contribute to working memory performance in healthy older adults.
KW - cognitive aging
KW - dorsolateral prefrontal cortex
KW - multimodal neuroimaging
KW - structural and functional magnetic resonance imaging
KW - working memory
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U2 - 10.1093/cercor/bhaa322
DO - 10.1093/cercor/bhaa322
M3 - Article
C2 - 33188384
AN - SCOPUS:85102090473
SN - 1047-3211
VL - 31
SP - 1732
EP - 1743
JO - Cerebral Cortex
JF - Cerebral Cortex
IS - 3
ER -