Independent Contributions of Dorsolateral Prefrontal Structure and Function to Working Memory in Healthy Older Adults

Nicole D. Evangelista; Andrew O'Shea; Jessica N. Kraft; Hanna K. Hausman; Emanuel M. Boutzoukas; Nicole R. Nissim; Alejandro Albizu; Cheshire Hardcastle; Emily J. Van Etten; Pradyumna K. Bharadwaj; Samantha G. Smith; Hyun Song; Georg A. Hishaw; Steven Dekosky; Samuel Wu; Eric Porges; Gene E. Alexander; Michael Marsiske; Ronald Cohen; Adam J. Woods

doi:10.1093/cercor/bhaa322

Independent Contributions of Dorsolateral Prefrontal Structure and Function to Working Memory in Healthy Older Adults

Nicole D. Evangelista, Andrew O'Shea, Jessica N. Kraft, Hanna K. Hausman, Emanuel M. Boutzoukas, Nicole R. Nissim, Alejandro Albizu, Cheshire Hardcastle, Emily J. Van Etten, Pradyumna K. Bharadwaj, Samantha G. Smith, Hyun Song, Georg A. Hishaw, Steven Dekosky, Samuel Wu, Eric Porges, Gene E. Alexander, Michael Marsiske, Ronald Cohen, Adam J. Woods

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Age-related differences in dorsolateral prefrontal cortex (DLPFC) structure and function have each been linked to working memory. However, few studies have integrated multimodal imaging to simultaneously investigate relationships among structure, function, and cognition. We aimed to clarify how specifically DLPFC structure and function contribute to working memory in healthy older adults. In total, 138 participants aged 65-88 underwent 3 T neuroimaging and were divided into higher and lower groups based on a median split of in-scanner n-back task performance. Three a priori spherical DLPFC regions of interest (ROIs) were used to quantify blood-oxygen-level-dependent (BOLD) signal and FreeSurfer-derived surface area, cortical thickness, and white matter volume. Binary logistic regressions adjusting for age, sex, education, and scanner type revealed that greater left and right DLPFC BOLD signal predicted the probability of higher performing group membership (P values<.05). Binary logistic regressions also adjusting for total intracranial volume revealed left DLPFC surface area that significantly predicted the probability of being in the higher performing group (P = 0.017). The left DLPFC BOLD signal and surface area were not significantly associated and did not significantly interact to predict group membership (P values>.05). Importantly, this suggests BOLD signal and surface area may independently contribute to working memory performance in healthy older adults.

Original language	English (US)
Pages (from-to)	1732-1743
Number of pages	12
Journal	Cerebral Cortex
Volume	31
Issue number	3
DOIs	https://doi.org/10.1093/cercor/bhaa322
State	Published - Mar 1 2021

Keywords

cognitive aging
dorsolateral prefrontal cortex
multimodal neuroimaging
structural and functional magnetic resonance imaging
working memory

ASJC Scopus subject areas

Cognitive Neuroscience
Cellular and Molecular Neuroscience

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10.1093/cercor/bhaa322

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Evangelista, N. D., O'Shea, A., Kraft, J. N., Hausman, H. K., Boutzoukas, E. M., Nissim, N. R., Albizu, A., Hardcastle, C., Van Etten, E. J., Bharadwaj, P. K., Smith, S. G., Song, H., Hishaw, G. A., Dekosky, S., Wu, S., Porges, E., Alexander, G. E., Marsiske, M., Cohen, R., & Woods, A. J. (2021). Independent Contributions of Dorsolateral Prefrontal Structure and Function to Working Memory in Healthy Older Adults. Cerebral Cortex, 31(3), 1732-1743. https://doi.org/10.1093/cercor/bhaa322

Evangelista, ND, O'Shea, A, Kraft, JN, Hausman, HK, Boutzoukas, EM, Nissim, NR, Albizu, A, Hardcastle, C, Van Etten, EJ, Bharadwaj, PK, Smith, SG, Song, H, Hishaw, GA, Dekosky, S, Wu, S, Porges, E, Alexander, GE, Marsiske, M, Cohen, R & Woods, AJ 2021, 'Independent Contributions of Dorsolateral Prefrontal Structure and Function to Working Memory in Healthy Older Adults', Cerebral Cortex, vol. 31, no. 3, pp. 1732-1743. https://doi.org/10.1093/cercor/bhaa322

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title = "Independent Contributions of Dorsolateral Prefrontal Structure and Function to Working Memory in Healthy Older Adults",

abstract = "Age-related differences in dorsolateral prefrontal cortex (DLPFC) structure and function have each been linked to working memory. However, few studies have integrated multimodal imaging to simultaneously investigate relationships among structure, function, and cognition. We aimed to clarify how specifically DLPFC structure and function contribute to working memory in healthy older adults. In total, 138 participants aged 65-88 underwent 3 T neuroimaging and were divided into higher and lower groups based on a median split of in-scanner n-back task performance. Three a priori spherical DLPFC regions of interest (ROIs) were used to quantify blood-oxygen-level-dependent (BOLD) signal and FreeSurfer-derived surface area, cortical thickness, and white matter volume. Binary logistic regressions adjusting for age, sex, education, and scanner type revealed that greater left and right DLPFC BOLD signal predicted the probability of higher performing group membership (P values<.05). Binary logistic regressions also adjusting for total intracranial volume revealed left DLPFC surface area that significantly predicted the probability of being in the higher performing group (P = 0.017). The left DLPFC BOLD signal and surface area were not significantly associated and did not significantly interact to predict group membership (P values>.05). Importantly, this suggests BOLD signal and surface area may independently contribute to working memory performance in healthy older adults.",

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doi = "10.1093/cercor/bhaa322",

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AU - Evangelista, Nicole D.

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AU - Kraft, Jessica N.

AU - Hausman, Hanna K.

AU - Boutzoukas, Emanuel M.

AU - Nissim, Nicole R.

AU - Albizu, Alejandro

AU - Hardcastle, Cheshire

AU - Van Etten, Emily J.

AU - Bharadwaj, Pradyumna K.

AU - Smith, Samantha G.

AU - Song, Hyun

AU - Hishaw, Georg A.

AU - Dekosky, Steven

AU - Wu, Samuel

AU - Porges, Eric

AU - Alexander, Gene E.

AU - Marsiske, Michael

AU - Cohen, Ronald

AU - Woods, Adam J.

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N2 - Age-related differences in dorsolateral prefrontal cortex (DLPFC) structure and function have each been linked to working memory. However, few studies have integrated multimodal imaging to simultaneously investigate relationships among structure, function, and cognition. We aimed to clarify how specifically DLPFC structure and function contribute to working memory in healthy older adults. In total, 138 participants aged 65-88 underwent 3 T neuroimaging and were divided into higher and lower groups based on a median split of in-scanner n-back task performance. Three a priori spherical DLPFC regions of interest (ROIs) were used to quantify blood-oxygen-level-dependent (BOLD) signal and FreeSurfer-derived surface area, cortical thickness, and white matter volume. Binary logistic regressions adjusting for age, sex, education, and scanner type revealed that greater left and right DLPFC BOLD signal predicted the probability of higher performing group membership (P values<.05). Binary logistic regressions also adjusting for total intracranial volume revealed left DLPFC surface area that significantly predicted the probability of being in the higher performing group (P = 0.017). The left DLPFC BOLD signal and surface area were not significantly associated and did not significantly interact to predict group membership (P values>.05). Importantly, this suggests BOLD signal and surface area may independently contribute to working memory performance in healthy older adults.

AB - Age-related differences in dorsolateral prefrontal cortex (DLPFC) structure and function have each been linked to working memory. However, few studies have integrated multimodal imaging to simultaneously investigate relationships among structure, function, and cognition. We aimed to clarify how specifically DLPFC structure and function contribute to working memory in healthy older adults. In total, 138 participants aged 65-88 underwent 3 T neuroimaging and were divided into higher and lower groups based on a median split of in-scanner n-back task performance. Three a priori spherical DLPFC regions of interest (ROIs) were used to quantify blood-oxygen-level-dependent (BOLD) signal and FreeSurfer-derived surface area, cortical thickness, and white matter volume. Binary logistic regressions adjusting for age, sex, education, and scanner type revealed that greater left and right DLPFC BOLD signal predicted the probability of higher performing group membership (P values<.05). Binary logistic regressions also adjusting for total intracranial volume revealed left DLPFC surface area that significantly predicted the probability of being in the higher performing group (P = 0.017). The left DLPFC BOLD signal and surface area were not significantly associated and did not significantly interact to predict group membership (P values>.05). Importantly, this suggests BOLD signal and surface area may independently contribute to working memory performance in healthy older adults.

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Independent Contributions of Dorsolateral Prefrontal Structure and Function to Working Memory in Healthy Older Adults

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