Increasing dissolution rates and gastrointestinal absorption of drugs via solid solutions and eutectic mixtures IV: Chloramphenicol—urea system

The dissolution rates of a number of chloramphenicol‐urea samples were studied. Solubility studies indicated that urea increased significantly the solubility of chloramphenicol; this resulted in a large increase in the initial dissolution rate of chloramphenicol from physically mixed samples of the drug with urea. The α solid solution of chloramphenicol in urea was found to dissolve twice as rapidly as a physical mixture of the same composition, and almost 4 times as rapidly as the pure drug.