Increasing dissolution rates and gastrointestinal absorption of drugs via solid solutions and eutectic mixtures IV: Chloramphenicol—urea system

Arthur H. Goldberg; Milo Gibaldi; Joseph L. Kanig; Michael Mayersohn

doi:10.1002/jps.2600550610

Increasing dissolution rates and gastrointestinal absorption of drugs via solid solutions and eutectic mixtures IV: Chloramphenicol—urea system

Arthur H. Goldberg, Milo Gibaldi, Joseph L. Kanig, Michael Mayersohn

Research output: Contribution to journal › Article › peer-review

116 Scopus citations

Abstract

The dissolution rates of a number of chloramphenicol‐urea samples were studied. Solubility studies indicated that urea increased significantly the solubility of chloramphenicol; this resulted in a large increase in the initial dissolution rate of chloramphenicol from physically mixed samples of the drug with urea. The α solid solution of chloramphenicol in urea was found to dissolve twice as rapidly as a physical mixture of the same composition, and almost 4 times as rapidly as the pure drug.

Original language	English (US)
Pages (from-to)	581-583
Number of pages	3
Journal	Journal of pharmaceutical sciences
Volume	55
Issue number	6
DOIs	https://doi.org/10.1002/jps.2600550610
State	Published - Jun 1966
Externally published	Yes

ASJC Scopus subject areas

Pharmaceutical Science

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abstract = "The dissolution rates of a number of chloramphenicol‐urea samples were studied. Solubility studies indicated that urea increased significantly the solubility of chloramphenicol; this resulted in a large increase in the initial dissolution rate of chloramphenicol from physically mixed samples of the drug with urea. The α solid solution of chloramphenicol in urea was found to dissolve twice as rapidly as a physical mixture of the same composition, and almost 4 times as rapidly as the pure drug.",

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year = "1966",

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AU - Mayersohn, Michael

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Increasing dissolution rates and gastrointestinal absorption of drugs via solid solutions and eutectic mixtures IV: Chloramphenicol—urea system

Abstract

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