@inproceedings{dc898960a8d44e34ade75b9502ad5adc,
title = "In vivo three-dimensional optical coherence tomography and multiphoton microscopy in a mouse model of ovarian neoplasia",
abstract = "Our goal is to use optical coherence tomography (OCT) and multiphoton microscopy (MPM) to detect early tumor development in a mouse model of ovarian neoplasia. We hope to use information regarding early tumor development to create a diagnostic test for high-risk patients. In this study we collect in vivo images using OCT, second harmonic generation and two-photon excited fluorescence from non-vinylcyclohexene diepoxide (VCD)-dosed and VCD-dosed mice. VCD causes follicular apoptosis (simulating menopause) and leads to tumor development. Using OCT and MPM we visualized the ovarian microstructure and were able to see differences between non-VCD-dosed and VCD-dosed animals. This leads us to believe that OCT and MPM may be useful for detecting changes due to early tumor development.",
keywords = "fluorescence microscopy, imaging, ovarian cancer, post-menopausal mouse model, second harmonic generation, two-photon excited fluorescence, vinylcyclohexene diepoxide",
author = "Watson, {Jennifer M.} and Marion, {Samuel L.} and Rice, {Photini Faith} and Bentley, {David L.} and David Besselsen and Urs Utzinger and Hoyer, {Patricia B} and Barton, {Jennifer K.}",
year = "2013",
doi = "10.1117/12.1000273",
language = "English (US)",
isbn = "9780819493460",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Optical Biopsy XI",
note = "Conference on Optical Biopsy XI ; Conference date: 05-02-2013 Through 06-02-2013",
}