Abstract
We compared the in vivo transport of zinc in segments of jejunum, ileum, and colon of 2-week-old (suckling) and 6-week-old (adolescent) rats. In normal rats, net absorption and lumen to mucosa flux of zinc, normalized for differences in size of the intestine (μmol/h/g dry weight) were significantly greater in all perfused segments of the suckling compared with corresponding segments of the adolescent rats (p < 0.05). Moreover, zinc transport rates in colonic segments of the suckling rats were significantly greater than corresponding transport rates in the small intestinal segments (p < 0.05). In the adolescent rats, transport rates in the colonic segments were similar to corre-sponding rates in the small intestinal segments. Growth retardation (pups raised with mothers fed a diet deficient in protein) appeared to have no effect on net absorption or lumen to mucosa flux of zinc in suckling rats, but significantly enhanced net absorption and lumen to mucosa flux of zinc in the adolescent rats.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 119-124 |
| Number of pages | 6 |
| Journal | Journal of pediatric gastroenterology and nutrition |
| Volume | 1 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1982 |
| Externally published | Yes |
Keywords
- Maturation of rats
- Small and large intestine
- Zinc transport
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Gastroenterology