In vivo induction of rat hepatic ornithine decarboxylase and plasminogen activator by 12-O-tetradecanoypphorbol 13-acetate

Arthur R. Buckley, Charles W. Putnam, Diane H. Russell

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Rapid and substantial elevations in ornithine decarboxylase and plasminogen activator have been linked to tumor promotion in mouse epidermis and in vitro. Systemic administration of 12-O-tetradecanoylphorbol 13-acetate (TPA) rapidly increased both enzymic activities in rat liver. Pretreatment with either cycloheximide or actinomycin D attenuated both enzyme inductions. It is concluded that: (1) systemic TPA rapidly induces plasminogen activator and ornithine decarboxylase activities in rat liver; and (2) both inductions reflect de novo enzyme synthesis.

Original languageEnglish (US)
Pages (from-to)127-130
Number of pages4
JournalBBA - General Subjects
Volume841
Issue number1
DOIs
StatePublished - Jul 26 1985
Externally publishedYes

Keywords

  • (Rat liver)
  • Enzyme inducion
  • Ornithine decarboxylase
  • Phorbol ester
  • Plasminogen activator

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology

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