In vivo bidirectional color Doppler flow imaging of picoliter blood volumes using optical coherence tomography

Joseph A. Izatt; Manish D. Kulkarni; Siavash Yazdanfar; Jennifer K. Barton; Ashley J. Welch

doi:10.1364/OL.22.001439

In vivo bidirectional color Doppler flow imaging of picoliter blood volumes using optical coherence tomography

Joseph A. Izatt, Manish D. Kulkarni, Siavash Yazdanfar, Jennifer K. Barton, Ashley J. Welch

Research output: Contribution to journal › Article › peer-review

616 Scopus citations

Abstract

We describe a novel optical system for bidirectional color Doppler imaging of flow in biological tissues with micrometer-scale resolution and demonstrate its use for in vivo imaging of blood flow in an animal model. Our technique, color Doppler optical coherence tomography (CDOCT), performs spatially localized optical Doppler velocimetry by use of scanning low-coherence interferometry. CDOCT is an extension of optical coherence tomography (OCT), employing coherent signal-acquisition electronics and joint time-frequency analysis algorithms to perform flow imaging simultaneous with conventional OCT imaging. Cross-sectional maps of blood flow velocity with <50-μm spatial resolution and <0.6-mm/s velocity precision were obtained through intact skin in living hamster subdermal tissue. This technology has several potential medical applications.

Original language	English (US)
Pages (from-to)	1439-1441
Number of pages	3
Journal	Optics letters
Volume	22
Issue number	18
DOIs	https://doi.org/10.1364/OL.22.001439
State	Published - Sep 15 1997
Externally published	Yes

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics

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10.1364/OL.22.001439

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title = "In vivo bidirectional color Doppler flow imaging of picoliter blood volumes using optical coherence tomography",

abstract = "We describe a novel optical system for bidirectional color Doppler imaging of flow in biological tissues with micrometer-scale resolution and demonstrate its use for in vivo imaging of blood flow in an animal model. Our technique, color Doppler optical coherence tomography (CDOCT), performs spatially localized optical Doppler velocimetry by use of scanning low-coherence interferometry. CDOCT is an extension of optical coherence tomography (OCT), employing coherent signal-acquisition electronics and joint time-frequency analysis algorithms to perform flow imaging simultaneous with conventional OCT imaging. Cross-sectional maps of blood flow velocity with <50-μm spatial resolution and <0.6-mm/s velocity precision were obtained through intact skin in living hamster subdermal tissue. This technology has several potential medical applications.",

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AU - Izatt, Joseph A.

AU - Kulkarni, Manish D.

AU - Yazdanfar, Siavash

AU - Barton, Jennifer K.

AU - Welch, Ashley J.

PY - 1997/9/15

Y1 - 1997/9/15

N2 - We describe a novel optical system for bidirectional color Doppler imaging of flow in biological tissues with micrometer-scale resolution and demonstrate its use for in vivo imaging of blood flow in an animal model. Our technique, color Doppler optical coherence tomography (CDOCT), performs spatially localized optical Doppler velocimetry by use of scanning low-coherence interferometry. CDOCT is an extension of optical coherence tomography (OCT), employing coherent signal-acquisition electronics and joint time-frequency analysis algorithms to perform flow imaging simultaneous with conventional OCT imaging. Cross-sectional maps of blood flow velocity with <50-μm spatial resolution and <0.6-mm/s velocity precision were obtained through intact skin in living hamster subdermal tissue. This technology has several potential medical applications.

AB - We describe a novel optical system for bidirectional color Doppler imaging of flow in biological tissues with micrometer-scale resolution and demonstrate its use for in vivo imaging of blood flow in an animal model. Our technique, color Doppler optical coherence tomography (CDOCT), performs spatially localized optical Doppler velocimetry by use of scanning low-coherence interferometry. CDOCT is an extension of optical coherence tomography (OCT), employing coherent signal-acquisition electronics and joint time-frequency analysis algorithms to perform flow imaging simultaneous with conventional OCT imaging. Cross-sectional maps of blood flow velocity with <50-μm spatial resolution and <0.6-mm/s velocity precision were obtained through intact skin in living hamster subdermal tissue. This technology has several potential medical applications.

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In vivo bidirectional color Doppler flow imaging of picoliter blood volumes using optical coherence tomography

Abstract

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