Abstract
The aim of this paper was to create an in vitro setup to quantify the oxygen offloading capabilities of dodecafluoropentane emulsion (DDFPe) in a hypoxic environment. Oxygen offloading from DDFPe was characterized under different gaseous environments and under pre-oxygenated conditions. Results of this study showed that (1) oxygen offloading is inversely related to the solubility of the selected sparging gas in saline and (2) both pre-oxygenated and simultaneously oxygenated DDFPe display similar magnitudes of oxygen transport. These results could be applicable to on-going and future studies involving a variety of hypoxic conditions where oxygen delivery might be therapeutically beneficial.
Original language | English (US) |
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Pages (from-to) | 783-789 |
Number of pages | 7 |
Journal | Artificial Cells, Nanomedicine and Biotechnology |
Volume | 47 |
Issue number | 1 |
DOIs | |
State | Published - Dec 4 2019 |
Keywords
- Dodecafluoropentane
- in vitro model
- oxygen therapeutic
- perfluorocarbon
- pre-oxygenation
ASJC Scopus subject areas
- Biotechnology
- Medicine (miscellaneous)
- Biomedical Engineering
- Pharmaceutical Science