In vitro model to compare the oxygen offloading behaviour of dodecafluoropentane emulsion (DDFPe)

Meghna S. Jayaraman; Kaitlin Graham; Evan C. Unger

doi:10.1080/21691401.2019.1577882

In vitro model to compare the oxygen offloading behaviour of dodecafluoropentane emulsion (DDFPe)

Meghna S. Jayaraman, Kaitlin Graham, Evan C. Unger

Cancer Center

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The aim of this paper was to create an in vitro setup to quantify the oxygen offloading capabilities of dodecafluoropentane emulsion (DDFPe) in a hypoxic environment. Oxygen offloading from DDFPe was characterized under different gaseous environments and under pre-oxygenated conditions. Results of this study showed that (1) oxygen offloading is inversely related to the solubility of the selected sparging gas in saline and (2) both pre-oxygenated and simultaneously oxygenated DDFPe display similar magnitudes of oxygen transport. These results could be applicable to on-going and future studies involving a variety of hypoxic conditions where oxygen delivery might be therapeutically beneficial.

Original language	English (US)
Pages (from-to)	783-789
Number of pages	7
Journal	Artificial Cells, Nanomedicine and Biotechnology
Volume	47
Issue number	1
DOIs	https://doi.org/10.1080/21691401.2019.1577882
State	Published - Dec 4 2019

Keywords

Dodecafluoropentane
in vitro model
oxygen therapeutic
perfluorocarbon
pre-oxygenation

ASJC Scopus subject areas

Biotechnology
Medicine (miscellaneous)
Biomedical Engineering
Pharmaceutical Science

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10.1080/21691401.2019.1577882

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abstract = "The aim of this paper was to create an in vitro setup to quantify the oxygen offloading capabilities of dodecafluoropentane emulsion (DDFPe) in a hypoxic environment. Oxygen offloading from DDFPe was characterized under different gaseous environments and under pre-oxygenated conditions. Results of this study showed that (1) oxygen offloading is inversely related to the solubility of the selected sparging gas in saline and (2) both pre-oxygenated and simultaneously oxygenated DDFPe display similar magnitudes of oxygen transport. These results could be applicable to on-going and future studies involving a variety of hypoxic conditions where oxygen delivery might be therapeutically beneficial.",

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In vitro model to compare the oxygen offloading behaviour of dodecafluoropentane emulsion (DDFPe)

Abstract

Keywords

ASJC Scopus subject areas

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